| Levels of VEGF-A mRNA in plasma from patients with colorectal carcinoma as possible surrogate marker of angiogenesis. | |
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MedLine Citation:
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PMID: 18461364 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: The regulator of angiogenesis most extensively studied is VEGF. VEGF mRNA in plasma from patients with colorectal cancer was analyzed as a possible surrogate marker of tumor angiogenesis. METHODS: VEGF mRNA was measured by quantitative PCR in plasma, tumors and circulating tumor cells from colorectal cancer patients. Circulating VEGF protein was analyzed by ELISA. Microvessel density was determined. RESULTS: Levels of VEGF mRNA and protein in plasma were higher in patients than in controls. VEGF mRNA was overexpressed in tumors with respect to normal tissues. Levels of VEGF protein were associated with VEGF mRNA in plasma, but no associations with tumor samples were found. A trend to statistical significance was shown between high VEGF mRNA and vascular invasion. MVD was not related to VEGF mRNA in plasma. CONCLUSIONS: Thus, VEGF mRNA could be a marker similar to VEGF protein in plasma. |
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Authors:
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Vanesa Garcia; Jose M Garcia; Javier Silva; Cristina Peña; Gemma Dominguez; Yolanda Lorenzo; Raquel Diaz; Isabel Alonso; Antonio Colas; Alicia Hurtado; Antonio Sanchez; Felix Bonilla |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-05-07 |
Journal Detail:
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Title: Journal of cancer research and clinical oncology Volume: 134 ISSN: 1432-1335 ISO Abbreviation: J. Cancer Res. Clin. Oncol. Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-10-08 Completed Date: 2009-01-27 Revised Date: 2009-03-17 |
Medline Journal Info:
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Nlm Unique ID: 7902060 Medline TA: J Cancer Res Clin Oncol Country: Germany |
Other Details:
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Languages: eng Pagination: 1165-71 Citation Subset: IM |
Affiliation:
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Department of Medical Oncology, Hospital Universitario Puerta de Hierro, C/San Martín de Porres, 4, 28035, Madrid, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Colorectal Neoplasms
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genetics*,
pathology*,
surgery DNA Primers Genetic Markers Humans Neovascularization, Pathologic / genetics*, pathology Polymerase Chain Reaction RNA, Messenger / genetics* RNA, Neoplasm / blood, genetics, isolation & purification Vascular Endothelial Growth Factor A / genetics* |
| Chemical | |
Reg. No./Substance:
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0/DNA Primers; 0/Genetic Markers; 0/RNA, Messenger; 0/RNA, Neoplasm; 0/Vascular Endothelial Growth Factor A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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