| Levels of Matrix Metalloproteinase-2 and -9 in the Cerebrospinal Fluid of Dogs with Visceral Leishmaniasis. | |
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MedLine Citation:
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PMID: 21332759 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Inflammation causes increases in the level of matrix metalloproteinases (MMPs), which, in central nervous system (CNS), are associated with neuroinflammation and disruption of blood-brain-barrier. Analysis of cerebrospinal fluid (CSF) is pivotal for detecting diseases in CNS and, although a specific diagnosis may not be achieved, this analysis is helpful to confirm the diagnosis or to rule out relevant differential diagnoses. This study examined the levels of MMP-2 and MMP-9 in the CSF of dogs using gelatin zymography to verify possible alterations in these enzymes during natural systemic infection with Leishmania chagasi. Latent and active forms of MMP-2 were detected in some dogs of both groups, with high levels in the control group. In contrast, latent and active forms of MMP-9 were detected only in some animals with leishmaniasis. These results clearly demonstrate that MMP-9 is elevated in CSF of dogs with VL. Although these results are preliminary, they suggest that MMP-9 might play a role in disruption of blood-brain-barrier and/or blood-CSF-barrier. While the presence of MMPs in CSF is not a condition exclusive to VL, their presence and persistence in CSF supports the hypothesis of an inflammatory state within CNS of dogs with VL. |
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Authors:
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Natalia Ribeiro Marangoni; Guilherme Dias de Melo; Olívia Campos de Moraes; Milena Sato de Souza; Silvia Helena Venturoli Perri; Gisele Fabrino Machado |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-19 |
Journal Detail:
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Title: Parasite immunology Volume: - ISSN: 1365-3024 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7910948 Medline TA: Parasite Immunol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Blackwell Publishing Ltd. |
Affiliation:
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Department of Animal Clinics, Surgery and Reproduction, School of Veterinary Medicine, UNESP - Univ Estadual Paulista, Araçatuba, São Paulo, Brazil Department of Animal Production and Health, School of Veterinary Medicine, UNESP - Univ Estadual Paulista, Araçatuba, São Paulo, Brazil. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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