| Levels of inflammatory markers and their correlation with dyslipidemia in diabetics. | |
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MedLine Citation:
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PMID: 19356332 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To measure the levels of inflammatory markers (serum ferritin and high sensitivity C-reactive protein) and dyslipidemia in diabetics and to find a correlation between these inflammatory markers and dyslipidemia. STUDY DESIGN: Comparative study. PLACE AND DURATION OF STUDY: Department of Biochemistry and Molecular Biology, Army Medical College, Rawalpindi, from March 2007 to February 2008. METHODOLOGY: The study included 30 known type-2 diabetic patients randomly inducted from diabetic clinics of Rawalpindi. Healthy volunteers (n=30) having blood glucose less than 6 mmol/L were inducted as the comparison group. Fasting blood samples of diabetics and controls were analyzed for glucose, glycated hemoglobin (HbA1c), lipid profile, high sensitivity C-reactive protein (hs-CRP) and serum ferritin. RESULTS: The diabetic subjects had significantly higher levels of glucose, HbA1c, total cholesterol, LDL cholesterol, triglycerides, hs-CRP and ferritin as compared to normal subjects (p<0.001), while the level of HDL cholesterol was significantly lower in diabetics (p<0.001). Furthermore, a significant positive correlation was found between the inflammatory markers, hs-CRP and ferritin, and the parameters of dyslipidemia i.e. total cholesterol, LDL cholesterol and triglycerides (p<0.001 r=0.72) except for HDL cholesterol, which had an insignificant negative correlation with the inflammatory markers (p>0.05 r=-0.10). CONCLUSION: Low-grade inflammation exists in Diabetes mellitus and it is positively related with dyslipidemia (except for HDL cholesterol) in diabetics. |
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Authors:
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Palvasha Waheed; Abdul Khaliq Naveed; Fareeha Farooq |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of the College of Physicians and Surgeons--Pakistan : JCPSP Volume: 19 ISSN: 1022-386X ISO Abbreviation: J Coll Physicians Surg Pak Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-04-09 Completed Date: 2010-01-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9606447 Medline TA: J Coll Physicians Surg Pak Country: Pakistan |
Other Details:
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Languages: eng Pagination: 207-10 Citation Subset: IM |
Affiliation:
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Department of Biochemistry and Molecular Biology, Army Medical College, Rawalpindi. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Biological Markers / blood* Blood Glucose / analysis C-Reactive Protein / analysis Case-Control Studies Cholesterol, HDL / blood Cholesterol, LDL / blood Diabetes Mellitus, Type 2 / blood, complications*, pathology Dyslipidemias / blood, complications*, diagnosis Female Ferritins / blood Hemoglobin A, Glycosylated / analysis Humans Inflammation / blood, complications*, pathology Male Middle Aged Statistics as Topic Triglycerides / blood Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Blood Glucose; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Hemoglobin A, Glycosylated; 0/Triglycerides; 9007-41-4/C-Reactive Protein; 9007-73-2/Ferritins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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