| Levels of Breast Milk PBDEs from Southern Taiwan and Their Potential Impact on Neurodevelopment. | |
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MedLine Citation:
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PMID: 21857391 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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In vivo studies have demonstrated that prenatal or neonatal exposure to polybrominated diphenyl ethers (PBDEs) causes developmental neurotoxicity. However, there is a lack of human data. Our hypothesis was that PBDEs would result in lower infant neurodevelopment scores. This is a post-hoc analysis of previous studies. Fourteen PBDEs in 70 breast milk were analyzed using a high-resolution gas chromatograph/high-resolution mass spectrometer. Infant neurodevelopment at the age of 8-12 months was determined using the Bayley Scales of Infants and Toddlers Development, third edition (Bayley-III). The median of Σ14PBDEs (the sum of 14 PBDE congeners) was 2.92 ng/g lipid. The Σ14PBDE concentrations were not correlated with Bayley-III scores on cognitive, language, motor, social-emotional, or adaptive behavior scales. A significantly inverse association between brominated diphenyl ether (BDE)-209 and the cognitive scale was found after multivariate stepwise linear regression analyses (B=-0.007, adjusted R=-0.224, p=0.032). In contrast, the language scale was positively correlated with BDE-196 (B=0.096, adjusted R=0.315, p=0.002). Our results are consistent with most in vivo studies, suggesting that prenatal or postnatal exposure to BDE-209 potentially delays the neurological development. ABBREVIATIONS:: |
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Authors:
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How-Ran Chao; Tsui-Chun Tsou; Huei-Lin Huang; Gou-Ping Chang-Chien |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-18 |
Journal Detail:
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Title: Pediatric research Volume: - ISSN: 1530-0447 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Environmental Science and Engineering [H.-R.C.], National Pingtung University of Science and Technology, Neipu, 912 Pingtung, Taiwan; Division of Environmental Health and Occupational Medicine [T.-C.T.], National Health Research Institutes, Zhunan, Miaoli County 350, Taiwan; Institute of Behavioral Medicine [H.-L.H.], Medical College, National Cheng Kung University, 701 Tainan City, Taiwan; Department of Chemical and Materials Engineering [G.-P.C.-C.], Cheng-Shiu University, 833 Kaohsiung City, Taiwan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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