Document Detail

Levels of Breast Milk PBDEs from Southern Taiwan and Their Potential Impact on Neurodevelopment.
MedLine Citation:
PMID:  21857391     Owner:  NLM     Status:  Publisher    
In vivo studies have demonstrated that prenatal or neonatal exposure to polybrominated diphenyl ethers (PBDEs) causes developmental neurotoxicity. However, there is a lack of human data. Our hypothesis was that PBDEs would result in lower infant neurodevelopment scores. This is a post-hoc analysis of previous studies. Fourteen PBDEs in 70 breast milk were analyzed using a high-resolution gas chromatograph/high-resolution mass spectrometer. Infant neurodevelopment at the age of 8-12 months was determined using the Bayley Scales of Infants and Toddlers Development, third edition (Bayley-III). The median of Σ14PBDEs (the sum of 14 PBDE congeners) was 2.92 ng/g lipid. The Σ14PBDE concentrations were not correlated with Bayley-III scores on cognitive, language, motor, social-emotional, or adaptive behavior scales. A significantly inverse association between brominated diphenyl ether (BDE)-209 and the cognitive scale was found after multivariate stepwise linear regression analyses (B=-0.007, adjusted R=-0.224, p=0.032). In contrast, the language scale was positively correlated with BDE-196 (B=0.096, adjusted R=0.315, p=0.002). Our results are consistent with most in vivo studies, suggesting that prenatal or postnatal exposure to BDE-209 potentially delays the neurological development. ABBREVIATIONS::
How-Ran Chao; Tsui-Chun Tsou; Huei-Lin Huang; Gou-Ping Chang-Chien
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-18
Journal Detail:
Title:  Pediatric research     Volume:  -     ISSN:  1530-0447     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-8-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Environmental Science and Engineering [H.-R.C.], National Pingtung University of Science and Technology, Neipu, 912 Pingtung, Taiwan; Division of Environmental Health and Occupational Medicine [T.-C.T.], National Health Research Institutes, Zhunan, Miaoli County 350, Taiwan; Institute of Behavioral Medicine [H.-L.H.], Medical College, National Cheng Kung University, 701 Tainan City, Taiwan; Department of Chemical and Materials Engineering [G.-P.C.-C.], Cheng-Shiu University, 833 Kaohsiung City, Taiwan.
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