Document Detail

Level of response suppression and amphetamine effects on negatively punished adjunctive licking.
MedLine Citation:
PMID:  16377962     Owner:  NLM     Status:  MEDLINE    
The purpose of the present study was to investigate whether the level of response suppression is a major determinant of the effect of D-amphetamine on negatively punished adjunctive drinking. Rats were initially exposed to a multiple fixed-time (FT) 30-s FT 30-s food delivery schedule. They were then divided into two groups and subjected to one of two different multiple schedules, FT 30-s FT 45-s or FT 30-s FT 90-s. The FT 45-s and FT 90-s components were signalled by a tone. Comparably high levels of adjunctive licking were observed in both FT 30-s components, intermediate licking levels in the FT 45-s component, and little licking in the FT 90-s component. Licking during the FT 30-s components was subsequently punished by lick-contingent signalled delays (by a blackout) in food delivery. The duration of such delays was adjusted to reduce licking to levels obtained in the FT 45-s or FT 90-s components, respectively for each of the two groups. Punished licking was increased by 0.3 and 1.0 mg/kg of D-amphetamine, an effect that was greater in the FT 30-s FT 90-s group. No increase in licking was observed in the FT 45-s component, but the 1.0 mg/kg dose also increased responding in the FT 90-s component. In general, no statistically significant differences were found between the effects of D-amphetamine on punished and unpunished schedule-induced licking. As licking decreased during the FT 90-s component when the punishment contingency was introduced in the alternate component, the punishment procedure and FT 30-s component were entirely removed. On this occasion, D-amphetamine failed to increase licking induced by the FT 90-s schedule. These results indicate that the level of response suppression might be a good indicator of the degree to which D-amphetamine shows antipunishment effects on adjunctive licking reduced by negative punishment procedures.
Angeles Pérez-Padilla; Ricardo Pellón
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Behavioural pharmacology     Volume:  17     ISSN:  0955-8810     ISO Abbreviation:  Behav Pharmacol     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2005-12-26     Completed Date:  2006-10-27     Revised Date:  2009-07-07    
Medline Journal Info:
Nlm Unique ID:  9013016     Medline TA:  Behav Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  43-9     Citation Subset:  IM    
Animal Behaviour Laboratories, Department of Basic Psychology I, Faculty of Psychology, National University for Distance Learning, Madrid, Spain.
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MeSH Terms
Appetitive Behavior / drug effects
Association Learning / drug effects
Central Nervous System Stimulants / pharmacology*
Dextroamphetamine / pharmacology*
Dose-Response Relationship, Drug
Drinking / drug effects*
Inhibition (Psychology)*
Rats, Wistar
Reinforcement Schedule
Reg. No./Substance:
0/Central Nervous System Stimulants; 51-64-9/Dextroamphetamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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