Document Detail


Level of in utero cocaine exposure and neonatal ultrasound findings.
MedLine Citation:
PMID:  10545554     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To assess whether there is an association between the level of in utero cocaine exposure and findings on neonatal cranial ultrasound, controlling for potentially confounding variables.
STUDY DESIGN: In a prospective longitudinal study, three cocaine exposure groups were defined by maternal report and infant meconium assay: unexposed, heavier cocaine exposure (>75th percentile self-reported days of use or of meconium benzoylecogonine concentration) or lighter cocaine exposure (all others). Neonatal ultrasounds from 241 well, term infants were read by a single radiologist who was masked to the exposure group.
RESULTS: Infants with lighter cocaine exposure did not differ from the unexposed infants on any ultrasound findings. After controlling for infant gender, gestational age, and birth weight z scores and for maternal parity, blood pressure in labor, ethnicity, and use of cigarettes, alcohol, and marijuana during pregnancy, the more heavily cocaine-exposed infants were more likely than the unexposed infants to show subependymal hemorrhage in the caudothalamic groove (covariate adjusted odds ratio: 3.88; 95% confidence interval: 1.45, 10.35).
CONCLUSIONS: This is the first study to demonstrate that ultrasound findings suggestive of vascular injury to the neonatal central nervous system are related to the level of prenatal cocaine exposure. Inconsistency in previous research in identifying an association between prenatal cocaine exposure and neonatal cranial ultrasound findings may reflect failure to consider dose effects.
Authors:
D A Frank; K M McCarten; C D Robson; M Mirochnick; H Cabral; H Park; B Zuckerman
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pediatrics     Volume:  104     ISSN:  0031-4005     ISO Abbreviation:  Pediatrics     Publication Date:  1999 Nov 
Date Detail:
Created Date:  1999-11-24     Completed Date:  1999-11-24     Revised Date:  2013-08-01    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1101-5     Citation Subset:  AIM; IM    
Affiliation:
Boston University School of Medicine, Harvard Medical School, Boston, Massachusetts, USA. dafrank@bu.edu
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MeSH Terms
Descriptor/Qualifier:
Cocaine / analogs & derivatives,  analysis
Cocaine-Related Disorders / complications*
Dose-Response Relationship, Drug
Echoencephalography*
Female
Fetus / drug effects
Humans
Infant, Newborn
Intracranial Hemorrhages / chemically induced*,  ultrasonography
Longitudinal Studies
Meconium / chemistry
Odds Ratio
Pregnancy
Pregnancy Complications*
Prospective Studies
Risk Factors
Grant Support
ID/Acronym/Agency:
DA 06532/DA/NIDA NIH HHS; M01 RR000533-290216/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
50-36-2/Cocaine; 5353I8I6YS/benzoylecgonine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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