| Level of in utero cocaine exposure and neonatal ultrasound findings. | |
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MedLine Citation:
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PMID: 10545554 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To assess whether there is an association between the level of in utero cocaine exposure and findings on neonatal cranial ultrasound, controlling for potentially confounding variables. Study DESIGN: In a prospective longitudinal study, three cocaine exposure groups were defined by maternal report and infant meconium assay: unexposed, heavier cocaine exposure (>75th percentile self-reported days of use or of meconium benzoylecogonine concentration) or lighter cocaine exposure (all others). Neonatal ultrasounds from 241 well, term infants were read by a single radiologist who was masked to the exposure group. RESULTS: Infants with lighter cocaine exposure did not differ from the unexposed infants on any ultrasound findings. After controlling for infant gender, gestational age, and birth weight z scores and for maternal parity, blood pressure in labor, ethnicity, and use of cigarettes, alcohol, and marijuana during pregnancy, the more heavily cocaine-exposed infants were more likely than the unexposed infants to show subependymal hemorrhage in the caudothalamic groove (covariate adjusted odds ratio: 3.88; 95% confidence interval: 1.45, 10.35). CONCLUSIONS: This is the first study to demonstrate that ultrasound findings suggestive of vascular injury to the neonatal central nervous system are related to the level of prenatal cocaine exposure. Inconsistency in previous research in identifying an association between prenatal cocaine exposure and neonatal cranial ultrasound findings may reflect failure to consider dose effects. |
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Authors:
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D A Frank; K M McCarten; C D Robson; M Mirochnick; H Cabral; H Park; B Zuckerman |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Pediatrics Volume: 104 ISSN: 0031-4005 ISO Abbreviation: Pediatrics Publication Date: 1999 Nov |
Date Detail:
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Created Date: 1999-11-24 Completed Date: 1999-11-24 Revised Date: 2011-01-24 |
Medline Journal Info:
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Nlm Unique ID: 0376422 Medline TA: Pediatrics Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1101-5 Citation Subset: AIM; IM |
Affiliation:
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Boston University School of Medicine, Harvard Medical School, Boston, Massachusetts, USA. dafrank@bu.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cocaine
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analogs & derivatives,
analysis Cocaine-Related Disorders / complications* Dose-Response Relationship, Drug Echoencephalography* Female Fetus / drug effects Humans Infant, Newborn Intracranial Hemorrhages / chemically induced*, ultrasonography Longitudinal Studies Meconium / chemistry Odds Ratio Pregnancy Pregnancy Complications* Prospective Studies Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
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DA 06532/DA/NIDA NIH HHS; M01 RR000533-290216/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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50-36-2/Cocaine; 519-09-5/benzoylecgonine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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