Document Detail

Level of S100B protein expression in the amnion at various gestational ages in the third trimester of normal pregnancies.
MedLine Citation:
PMID:  17653874     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: S100B protein is a unique calcium-binding protein. Its biological role within the cell populations is not completely defined. Some pathological conditions that develop during pregnancy could affect S100B concentrations in the amniotic fluid, cord blood, and maternal serum. The aim of our study was to assess the correlation between S100B protein expression in the amnion, amniotic fluid and gestational age in the third trimester of uncomplicated pregnancies. METHODS: Amnion, amniotic fluid, maternal peripheral and umbilical cord blood samples were collected from healthy women who delivered at 31-36 weeks (n=17), 37-40 weeks (n=22), and 41-42 weeks (n=21). The expression of S100B in the amnion was assessed by immunohistochemistry and real-time (RT)-PCR, and its concentrations in amniotic fluid, maternal and cord blood sera were determined by ELISA. RESULTS: The S100B protein expression in the amnion and its concentrations in amniotic fluid, maternal and cord blood sera of patients in the third trimester were not significantly different at various gestational ages. CONCLUSIONS: The S100B protein expression in the amnion and the S100B protein concentrations in amniotic fluid, maternal and cord blood do not vary significantly in the third trimester of uncomplicated pregnancies.
Ekaterine Tskitishvili; Yoshiko Komoto; Yukiko Kinugasa; Takeshi Kanagawa; Mihyon Song; Kazuya Mimura; Takuji Tomimatsu; Tadashi Kimura; Koichiro Shimoya
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  86     ISSN:  0001-6349     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  2007  
Date Detail:
Created Date:  2007-07-26     Completed Date:  2007-10-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  915-20     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita City, Osaka, Japan.
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MeSH Terms
Amnion / metabolism*
Amniotic Fluid / metabolism*
Enzyme-Linked Immunosorbent Assay
Fetal Blood
Gestational Age
Nerve Growth Factors / blood,  genetics,  metabolism*
Polymerase Chain Reaction
Pregnancy Trimester, Third
RNA / analysis
Reference Values
S100 Proteins / blood,  genetics,  metabolism*
Reg. No./Substance:
0/Nerve Growth Factors; 0/S-100 calcium-binding protein beta subunit; 0/S100 Proteins; 63231-63-0/RNA

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