| Leukotrienes stimulate acid secretion from isolated gastric parietal cells. | |
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MedLine Citation:
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PMID: 6311197 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Leukotrienes LTC4 and LTD4 display contractile effect on the stomach. The stimulation of acid secretion by LTC4, LTD4 and LTE4 was evidenced on a crude isolated cell preparation from rabbit gastric mucosa using the (14C)aminopyrine accumulation method. LTs were in the same order of potency. No potentiation with histamine, carbachol or IBMX was observed suggesting a specific mechanism for LTs on parietal cell. |
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Authors:
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R Magous; J P Bali; J C Rossi; J P Girard |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 114 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 1983 Aug |
Date Detail:
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Created Date: 1983-10-28 Completed Date: 1983-10-28 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 897-900 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carbachol / pharmacology Culture Techniques Gastric Juice / secretion* Gastric Mucosa / drug effects*, secretion Histamine / pharmacology Leukotriene B4 / pharmacology* Rabbits SRS-A / pharmacology* Secretory Rate / drug effects Stimulation, Chemical |
| Chemical | |
Reg. No./Substance:
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0/SRS-A; 51-45-6/Histamine; 51-83-2/Carbachol; 71160-24-2/Leukotriene B4 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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