| Leukotriene release from neutrophils of patients on hemodialysis with cellulose membranes. | |
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MedLine Citation:
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PMID: 1313396 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The role of cytokines in patients with chronic renal failure is currently under investigation. We therefore studied the release of leukotriene B4 (LTB4) from polymorphonuclear leukocytes (PMN) in stable dialysis patients treated with two different cellulose membranes, Cuprophan and Hemophan, a modified cellulose with less complement activation. Six patients were treated for four weeks with Cuprophan then switched to Hemophan for another four weeks. Before and after the last treatment of each period, PMN were separated from 20 ml heparinized blood by FICOLL density gradient centrifugation. Portions of 5 x 10(6) PMN were resuspended in Hanks' buffer and stimulated for 5 minutes with calcium ionophore A23187 (5 micrograms/ml). LTB4 in cell supernatants was determined by specific radioimmunoassay. PMN from dialysis patients before HD released significantly (p less than 0.01) more LTB4 than healthy donors. No significant difference between pre- and post-dialysis values was observed with Cuprophan or Hemophan dialyzers. Our data suggest that the acute effects of blood membrane interaction with either complement activating or non-activating dialyzers do not lead to changes in post-dialysis leukotriene metabolism, but leukotriene production is enhanced chronically in dialysis patients. |
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Authors:
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A Jörres; D Jörres; G M Gahl; E Schulz; A Mahiout |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The International journal of artificial organs Volume: 15 ISSN: 0391-3988 ISO Abbreviation: Int J Artif Organs Publication Date: 1992 Feb |
Date Detail:
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Created Date: 1992-05-07 Completed Date: 1992-05-07 Revised Date: 2006-04-17 |
Medline Journal Info:
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Nlm Unique ID: 7802649 Medline TA: Int J Artif Organs Country: ITALY |
Other Details:
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Languages: eng Pagination: 84-8 Citation Subset: IM |
Affiliation:
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Rudolf Virchow University Clinic, Berlin-Charlottenberg, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Cellulose / analogs & derivatives* Humans Kidney Failure, Chronic / blood, therapy* Leukocyte Count Leukotriene B4 / metabolism* Membranes, Artificial Middle Aged Neutrophils / metabolism* Renal Dialysis* |
| Chemical | |
Reg. No./Substance:
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0/Membranes, Artificial; 106254-94-8/Hemophan; 71160-24-2/Leukotriene B4; 9004-34-6/Cellulose; 9050-09-3/cuprammonium cellulose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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