Document Detail

Leukotriene C4 regulation of splanchnic blood flow during ischemia.
MedLine Citation:
PMID:  8209929     Owner:  NLM     Status:  MEDLINE    
The role of endogenous splanchnic eicosanoids in mediating splanchnic vasoconstriction induced by the leukotriene C4 (LTC4) was examined during mild hemorrhage/reperfusion injury. Male Sprague-Dawley rats were anesthetized and subjected to sham or acute hemorrhage for 30 minutes, to 30 mm Hg, followed by blood reperfusion (SK+R). The superior mesenteric artery was cannulated and removed with its end-organ intestine (SV+SI preparation) and perfused in vitro with oxygenated Krebs-Henseleit buffer. Perfusion pressure was constantly recorded. Net SV+SI release of 6-keto-PGF1 alpha, PGE2 and thromboxane B2 were analyzed by enzyme immunoassay after LTC4 stimulation. Leukotriene C4 increased perfusion pressure and decreased the ratio of 6-keto-PGF1 alpha to thromboxane release (but not PGE2 to thromboxane B2) in the sham group. Hemorrhage/reperfusion increased perfusion pressure and decreased the ratio of 6-keto-PGF1 alpha to thromboxane B2. Mild hemorrhage/reperfusion increased LTC4-induced splanchnic vasoconstriction in part by decreasing the release ratio of endogenous splanchnic PGI2 to thromboxane B2.
S I Myers; R Hernandez
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of surgery     Volume:  167     ISSN:  0002-9610     ISO Abbreviation:  Am. J. Surg.     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-07-14     Completed Date:  1994-07-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370473     Medline TA:  Am J Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  566-9     Citation Subset:  AIM; IM    
Department of Surgery, University of Texas Southwestern Medical Center, Dallas.
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MeSH Terms
Analysis of Variance
Hemorrhage / physiopathology*
Immunoenzyme Techniques
Leukotriene C4 / pharmacology,  physiology*
Rats, Sprague-Dawley
Reperfusion Injury / physiopathology*
Splanchnic Circulation / drug effects,  physiology*
Thromboxane B2 / physiology*
Vasoconstriction / physiology
Grant Support
38342//PHS HHS
Reg. No./Substance:
54397-85-2/Thromboxane B2; 72025-60-6/Leukotriene C4

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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