| Leukotriene C4 regulation of splanchnic blood flow during ischemia. | |
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MedLine Citation:
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PMID: 8209929 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The role of endogenous splanchnic eicosanoids in mediating splanchnic vasoconstriction induced by the leukotriene C4 (LTC4) was examined during mild hemorrhage/reperfusion injury. Male Sprague-Dawley rats were anesthetized and subjected to sham or acute hemorrhage for 30 minutes, to 30 mm Hg, followed by blood reperfusion (SK+R). The superior mesenteric artery was cannulated and removed with its end-organ intestine (SV+SI preparation) and perfused in vitro with oxygenated Krebs-Henseleit buffer. Perfusion pressure was constantly recorded. Net SV+SI release of 6-keto-PGF1 alpha, PGE2 and thromboxane B2 were analyzed by enzyme immunoassay after LTC4 stimulation. Leukotriene C4 increased perfusion pressure and decreased the ratio of 6-keto-PGF1 alpha to thromboxane release (but not PGE2 to thromboxane B2) in the sham group. Hemorrhage/reperfusion increased perfusion pressure and decreased the ratio of 6-keto-PGF1 alpha to thromboxane B2. Mild hemorrhage/reperfusion increased LTC4-induced splanchnic vasoconstriction in part by decreasing the release ratio of endogenous splanchnic PGI2 to thromboxane B2. |
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Authors:
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S I Myers; R Hernandez |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of surgery Volume: 167 ISSN: 0002-9610 ISO Abbreviation: Am. J. Surg. Publication Date: 1994 Jun |
Date Detail:
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Created Date: 1994-07-14 Completed Date: 1994-07-14 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370473 Medline TA: Am J Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 566-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Surgery, University of Texas Southwestern Medical Center, Dallas. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Hemorrhage / physiopathology* Immunoenzyme Techniques Leukotriene C4 / pharmacology, physiology* Male Rats Rats, Sprague-Dawley Reperfusion Injury / physiopathology* Splanchnic Circulation / drug effects, physiology* Thromboxane B2 / physiology* Vasoconstriction / physiology |
| Grant Support | |
ID/Acronym/Agency:
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38342//PHS HHS |
| Chemical | |
Reg. No./Substance:
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54397-85-2/Thromboxane B2; 72025-60-6/Leukotriene C4 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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