Document Detail

Leukotriene B4 and peptido-leukotriene levels during radiographic contrast media infusion.
MedLine Citation:
PMID:  1345029     Owner:  NLM     Status:  MEDLINE    
The pathogenic mechanisms of radiographic contrast media (CM) reactions are still not well understood. Recently it has been proposed that leukotrienes (LT) may be involved in CM reactions. We measured plasma LTB4 and peptido-LT levels in 20 subjects undergoing urography with 2 low osmolality CM (ioxaglate and iopamidol) in order to elucidate if CM infusion determines LT release in plasma. LTB4 and peptido-LT did not change significantly during infusion of the 2 CM. Blood pressure, heart rate, and the number of circulating granulocytes were not affected by CM infusions, further evidence that LT release did not occur. We conclude therefore that LT are not released during infusion with the CM studied.
M Gardinali; C Pozzato; L Conciato; M Di Bello; A Calcagno; C Uslenghi; A Agostoni
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Acta radiologica (Stockholm, Sweden : 1987)     Volume:  33     ISSN:  0284-1851     ISO Abbreviation:  Acta Radiol     Publication Date:  1992 Mar 
Date Detail:
Created Date:  1992-05-20     Completed Date:  1992-05-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8706123     Medline TA:  Acta Radiol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  160-3     Citation Subset:  IM    
Clinica Medica, Ospedale San Paolo, Università di Milano, Italy.
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MeSH Terms
Contrast Media / pharmacology*
Iopamidol / pharmacology
Ioxaglic Acid / pharmacology
Leukotriene B4 / blood*
Leukotriene E4
SRS-A / analogs & derivatives*,  blood*
Urography / methods
Reg. No./Substance:
0/Contrast Media; 0/SRS-A; 59017-64-0/Ioxaglic Acid; 62883-00-5/Iopamidol; 71160-24-2/Leukotriene B4; 75715-89-8/Leukotriene E4

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