Document Detail


Leukotriene B4 in cows with normal calving, and in cows with retained fetal membranes and/or uterine subinvolution.
MedLine Citation:
PMID:  8269369     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two experiments were performed to study the relationship between leukotriene B4 (LTB4) synthesis and placental separation and uterine involution in the cow. In experiment I, the concentration and synthesis of LTB4 by caruncular tissue was lower in cows with retained fetal membranes (RFM cows, n = 11) than in cows that expelled the fetal membranes normally (NFM cows, n = 19). The presence of bacterial cell wall, especially of alpha-hemolytic streptococci and coagulase positive staphylococci enhanced LTB4 synthesis by allantochorion only in NFM cows. In the RFM group, Escherichia coli lipopolysaccharide decreased allantochorionic LTB4 synthesis. With caruncle, only epidermal growth factor increased LTB4 production in NFM cows. In experiment II, the caruncular and endometrial secretion of LTB4 was lower in cows with subuterine involution (SUI cows, n = 5) or cows with SUI and RFM (SUI+RFM cows, n = 4) than in cows with normal uterine involution (NUI cows, n = 8). This decrease was especially noticeable in the previously gravid horn. In the three uterine involution groups, there were no differences in LTB4 synthesis by caruncular tissue taken from the previously gravid horn. However, progesterone and a bacterial suspension of E. coli reduced the synthesis of LTB4. Estradiol had no effect on LTB4 synthesis at the end of the postpartum period. These results suggest that LTB4 may play an important role in both placental separation and uterine involution in cattle and LTB4 synthesis may be modulated by endocrine and bacterial factors.
Authors:
H Slama; D Vaillancourt; A K Goff
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Canadian journal of veterinary research = Revue canadienne de recherche vétérinaire     Volume:  57     ISSN:  0830-9000     ISO Abbreviation:  Can. J. Vet. Res.     Publication Date:  1993 Oct 
Date Detail:
Created Date:  1994-01-31     Completed Date:  1994-01-31     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  8607793     Medline TA:  Can J Vet Res     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  293-9     Citation Subset:  IM    
Affiliation:
Département de médecine, Université de Montréal, Faculté de Médecine vétérinaire, Sainte-Hyacinthe, Québec.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cattle
Cattle Diseases / metabolism*
Escherichia coli
Estradiol / pharmacology
Extraembryonic Membranes / drug effects,  metabolism
Female
Leukotriene B4 / biosynthesis*
Lipopolysaccharides / pharmacology
Placenta / drug effects,  metabolism*
Placenta Diseases / metabolism,  veterinary
Postpartum Period / metabolism*
Pregnancy
Progesterone / pharmacology
Puerperal Disorders / metabolism,  veterinary*
Uterine Diseases / metabolism,  veterinary
Chemical
Reg. No./Substance:
0/Lipopolysaccharides; 50-28-2/Estradiol; 57-83-0/Progesterone; 71160-24-2/Leukotriene B4
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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