| Leukotriene B4 and 20-OH-LTB4 in purulent peritoneal exudates demonstrated by GC-MS. | |
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MedLine Citation:
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PMID: 3016754 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Inflammatory peritoneal exudates from 11 patients with purulent peritonitis or non-perforative appendicitis were analyzed by gas chromatography mass spectrometry (GC-MS) for their content of 5S, 12R-dihydroxy-6,14-cis-8,10-trans-eicosatetraenoic acid (LTB4) and its omega-oxidized catabolite, 5S,12R,20-trihydroxy-6,8,10,14-eicosatetraenoic acid (20-OH-LTB4). Eleven samples of peritoneal exudates were examined. LTB4 and 20-OH-LTB4 were demonstrated only in the samples from patients with purulent peritonitis. LTB4 was detected in 4 samples, and 20-OH-LTB4 was detected in 6 samples by GC-MS with selected ion monitoring. In addition, a nearly full spectrum corresponding to that of synthetic 20-OH-LTB4 was obtained with 3 samples. Neither LTB4 nor 20-OH-LTB4 were detected in samples from patients with non-perforative appendicitis. LTB4 or 20-OH-LTB4 may be related to the pathophysiological mechanism of purulent inflammations. |
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Authors:
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Y Kikawa; Y Shigematsu; M Sudo |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Prostaglandins, leukotrienes, and medicine Volume: 23 ISSN: 0262-1746 ISO Abbreviation: Prostaglandins Leukot Med Publication Date: 1986 Jul |
Date Detail:
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Created Date: 1986-09-25 Completed Date: 1986-09-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8206868 Medline TA: Prostaglandins Leukot Med Country: SCOTLAND |
Other Details:
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Languages: eng Pagination: 85-94 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Appendicitis
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metabolism Ascitic Fluid / metabolism* Gas Chromatography-Mass Spectrometry Humans Inflammation / metabolism Leukotriene B4 / analogs & derivatives*, analysis, metabolism* Peritonitis / metabolism |
| Chemical | |
Reg. No./Substance:
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71160-24-2/Leukotriene B4; 79008-24-5/5,12,20-trihydroxy-6,8,10,14-eicosatetraenoic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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