Document Detail

Leukoencephalopathy induced by chemotherapy with tegafur, a 5-fluorouracil derivative.
MedLine Citation:
PMID:  9829818     Owner:  NLM     Status:  MEDLINE    
We report an autopsy case of a 64 year-old Japanese man diagnosed as having leukoencephalopathy caused by tegafur, a 5-fluorouracil derivative, and review seven previous cases, mostly reported in Japan. In the present case, tegafur had been orally administered for the shortest period of 3 weeks in pre- and postoperative cancer chemotherapy. He died 2 years later after having made a slight recovery from a prolonged akinetic mute state. Unlike similar cases previously reported, the degeneration of the white matter was most prominent in the temporal lobes. Histologically, the severely involved white matter showed nearly complete myelin and axonal loss with a proliferation of hypertrophic astrocytes. In the less severely involved areas, such as in the frontal white matter where myelin was relatively well preserved, numerous activated microglial cells and a small number of T lymphocytes were identified immunohistochemically. The cerebral cortex, cerebellum and brain stem were well preserved, which is consistent with the previous reports. Literature review revealed that the histopathological features of the lesions reported in human cases are quite different from those reported in animal experiments.
S Ohara; R Hayashi; S Hata; N Itoh; N Hanyu; K Yamamoto
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Acta neuropathologica     Volume:  96     ISSN:  0001-6322     ISO Abbreviation:  Acta Neuropathol.     Publication Date:  1998 Nov 
Date Detail:
Created Date:  1999-01-22     Completed Date:  1999-01-22     Revised Date:  2007-11-09    
Medline Journal Info:
Nlm Unique ID:  0412041     Medline TA:  Acta Neuropathol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  527-31     Citation Subset:  IM    
Department of Neurology, National Chushin-Matsumoto Hospital, Japan.
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MeSH Terms
Antimetabolites, Antineoplastic / adverse effects*
Brain / metabolism,  pathology
Brain Diseases / chemically induced*,  diagnosis,  metabolism,  pathology
Fatal Outcome
Frontal Lobe / metabolism,  pathology
Magnetic Resonance Imaging
Middle Aged
Tegafur / adverse effects*
Reg. No./Substance:
0/Antimetabolites, Antineoplastic; 17902-23-7/Tegafur

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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