Document Detail


Leukocytosis in Polycythemia Vera and Splenomegaly in Essential Thrombocythemia Are Independent Risk Factors for Hemorrhage.
MedLine Citation:
PMID:  23281576     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Long-term outcomes are favorable for patients with polycythemia vera (PV) and for patients with essential thrombocythemia (ET). However, hemorrhage is a significant cause of morbidity and mortality in those patients. METHODS: We retrospectively recruited 247 patients who had received a diagnosis of PV (n=101) or ET (n=146) during the period 2001 to 2010. RESULTS: After a median follow-up period of 36.2 months, the cumulative incidence of hemorrhage was 39.6% in patients with PV (6.2% per person-year) and 29.7% in patients with ET (5.9% person-years). Episodes of major bleeding occurred in 9.9% of patients with PV and in 14.4% of patients with ET. Overall survival was significantly shorter among patients with hemorrhage than among those without said complication (p<0.001 for overall patients; p=0.002 for PV patients; p=0.026 for ET patients). In the univariate analysis, age ≥ 60 years (OR: 4.77, p=0.046) and WBC ≥ 16 x10(9) /L (OR: 4.15, p=0.010) were predictors of hemorrhage in PV patients, and age ≥ 60 years (OR: 3.25, p=0.040), WBC ≥ 16 x10(9) /L (OR: 2.89, p=0.024), albumin <4.0 g/dl (OR: 4.10, p=0.002), and splenomegaly (OR: 5.19, p=0.002) were predictors of hemorrhage in ET patients. Multivariate analysis showed that WBC ≥ 16 x 10(9) / L was the only significant risk factor for hemorrhage in PV patients (OR: 3.51, p=0.026) and that splenomegaly was the only risk factor for hemorrhage in ET patients (OR: 3.00, p=0.048). CONCLUSION: Leukocytosis in PV and splenomegaly in ET are independent risk factors for hemorrhage. © 2013 John Wiley & Sons A/S.
Authors:
Yi-Sheng Chou; Jyh-Pyng Gau; Yuan-Bin Yu; Jih-Tung Pai; Liang-Tsai Hsiao; Jin-Hwang Liu; Ying-Chung Hong; Chun-Yu Liu; Ching-Fen Yang; Po-Min Chen; Tzeon-Jye Chiou; Cheng-Hwai Tzeng
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-3
Journal Detail:
Title:  European journal of haematology     Volume:  -     ISSN:  1600-0609     ISO Abbreviation:  Eur. J. Haematol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8703985     Medline TA:  Eur J Haematol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 John Wiley & Sons A/S.
Affiliation:
Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; National Yang-Ming University School of Medicine, Taipei, Taiwan.
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