Document Detail


Leukocytoclastic vasculitis. A cutaneous expression of immune complex disease.
MedLine Citation:
PMID:  6211146     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thirty-nine patients with clinical, histologic, and immunofluorescence evidence of leukocytoclastic (necrotizing) vasculitis were studied for the presence of circulating immune complexes. These patients were selected prospectively during a three-year interval from patients seen in a dermatology clinic. Clinical and serologic data are summarized and representative cases are presented. This large series of patients with leukocytoclastic vasculitis emphasizes both the frequency of this disorder and the varied disease settings within which it may manifest. The immunopathologic data presented support an immune complex-mediated pathogenesis for this disease process.
Authors:
S E Mackel; R E Jordon
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of dermatology     Volume:  118     ISSN:  0003-987X     ISO Abbreviation:  Arch Dermatol     Publication Date:  1982 May 
Date Detail:
Created Date:  1982-07-08     Completed Date:  1982-07-08     Revised Date:  2008-03-17    
Medline Journal Info:
Nlm Unique ID:  0372433     Medline TA:  Arch Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  296-301     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Complement Activating Enzymes / metabolism
Complement C1q
Female
Humans
Immune Complex Diseases / pathology*
Leukocytes / pathology
Male
Middle Aged
Necrosis
Rheumatoid Factor / analysis
Skin / blood supply
Skin Diseases / etiology,  immunology*,  pathology
Vasculitis / etiology,  immunology*,  pathology
Grant Support
ID/Acronym/Agency:
1F32AM0637-01/AM/NIADDK NIH HHS; AI-14550/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
80295-33-6/Complement C1q; 9009-79-4/Rheumatoid Factor; EC 3.-/Complement Activating Enzymes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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