Document Detail

Leukocytes in Complex Regional Pain Syndrome type I.
MedLine Citation:
PMID:  17080317     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The pathophysiology of Complex Regional Pain Syndrome type I (CRPS I) is unclear. An inflammatory reaction may cause the syndrome in which leukocytes may play an important role. MATERIALS AND METHODS: In this pilot study of six patients with acute warm CRPS I, we performed radiolabeled autologous leukocyte scans of both hands, in order to assess leukocyte accumulation. Comparison was made with the unaffected limb, and with three control patients with a Colles fracture without CRPS I. RESULTS: Images of the CRPS I patients obtained 4 h after leukocyte injection provided the clearest results. At 4 h post-injection, there was clear, asymmetrical leukocyte accumulation in the affected extremity with a mean ratio of 1.49+/-0.19. In control patients, no asymmetry was observed between hands (mean ratio 1.09+/-0.06), indicating the absence of specific leukocyte accumulation. There was a statistically significant difference between CRPS I and control subjects 4 h post injection (p=0.012). CONCLUSION: We found a significantly increased accumulation of leukocytes in patients with CRPS I. This is the first study to show a possible role for leukocytes in the pathophysiology of acute CRPS I.
Edward C T H Tan; Wim J G Oyen; R Jan A Goris
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Inflammation     Volume:  29     ISSN:  0360-3997     ISO Abbreviation:  Inflammation     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2006-11-30     Completed Date:  2007-03-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600105     Medline TA:  Inflammation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  182-6     Citation Subset:  IM    
Department of General Surgery - Section Traumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
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MeSH Terms
Colles' Fracture / complications*,  radionuclide imaging
Hand / radionuclide imaging*
Leukocyte Transfusion
Leukocytes / radionuclide imaging*
Middle Aged
Pilot Projects
Reflex Sympathetic Dystrophy / etiology*,  radionuclide imaging*
Technetium Tc 99m Exametazime
Time Factors
Reg. No./Substance:
0/Radiopharmaceuticals; 100504-35-6/Technetium Tc 99m Exametazime

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