Document Detail


Leukocytes, cell adhesion molecules and ischemic acute renal failure.
MedLine Citation:
PMID:  9150459     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ischemic acute renal failure (ARF) is a common clinical syndrome, associated with high morbidity and mortality, for which there is no specific therapy. Polymorphonuclear neutrophils (PMN) recruited during reperfusion have been implicated as mediators of renal parenchymal injury in ischemic ARF. Leukocyte adhesion molecules appear to facilitate PMN recruitment in this setting. Complementary studies using monoclonal antibodies, antisense oligonucleotides and gene "knock-out" indicate that blockade of CD11/CD18 integrins and intercellular adhesion molecule-1 (ICAM-1) attenuates ARF in some experimental models of renal ischemia. These exciting observations may herald the development of novel anti-adhesion strategies for use in human disease.
Authors:
H Rabb; Y M O'Meara; P Maderna; P Coleman; H R Brady
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Kidney international     Volume:  51     ISSN:  0085-2538     ISO Abbreviation:  Kidney Int.     Publication Date:  1997 May 
Date Detail:
Created Date:  1997-07-03     Completed Date:  1997-07-03     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0323470     Medline TA:  Kidney Int     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1463-8     Citation Subset:  IM    
Affiliation:
Division of Nephrology and Hypertension, University of South Florida, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Adhesion Molecules / physiology*
Cell Movement
Humans
Ischemia / etiology*
Kidney Failure, Acute / etiology*,  therapy
Leukocytes / physiology*
Reperfusion Injury / etiology
Chemical
Reg. No./Substance:
0/Cell Adhesion Molecules

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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