Document Detail

Leukocytes, cell adhesion molecules and ischemic acute renal failure.
MedLine Citation:
PMID:  9150459     Owner:  NLM     Status:  MEDLINE    
Ischemic acute renal failure (ARF) is a common clinical syndrome, associated with high morbidity and mortality, for which there is no specific therapy. Polymorphonuclear neutrophils (PMN) recruited during reperfusion have been implicated as mediators of renal parenchymal injury in ischemic ARF. Leukocyte adhesion molecules appear to facilitate PMN recruitment in this setting. Complementary studies using monoclonal antibodies, antisense oligonucleotides and gene "knock-out" indicate that blockade of CD11/CD18 integrins and intercellular adhesion molecule-1 (ICAM-1) attenuates ARF in some experimental models of renal ischemia. These exciting observations may herald the development of novel anti-adhesion strategies for use in human disease.
H Rabb; Y M O'Meara; P Maderna; P Coleman; H R Brady
Related Documents :
9617569 - Activated human neutrophils express vascular endothelial growth factor (vegf).
3514759 - Chemotactic peptides modulate adherence of human polymorphonuclear leukocytes to monola...
2941379 - Function of phagocytes in experimentally induced colitis in rabbits. i. the arthus phen...
2826199 - Sgp140: identification of a novel component on human polymorphonuclear leukocyte cell s...
680949 - The influence of chemotactic factors on neutrophil adhesiveness.
17971499 - Attenuated translocation of group iva phospholipase a2 and up-regulated annexin-1 synth...
12190939 - Integrin expression in the dermis during scar formation in humans.
8889489 - Early albumin leakage in pulmonary endothelial monolayers exposed to varying levels of ...
7752379 - Enuresis in sickle cell disease.
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Kidney international     Volume:  51     ISSN:  0085-2538     ISO Abbreviation:  Kidney Int.     Publication Date:  1997 May 
Date Detail:
Created Date:  1997-07-03     Completed Date:  1997-07-03     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0323470     Medline TA:  Kidney Int     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1463-8     Citation Subset:  IM    
Division of Nephrology and Hypertension, University of South Florida, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cell Adhesion Molecules / physiology*
Cell Movement
Ischemia / etiology*
Kidney Failure, Acute / etiology*,  therapy
Leukocytes / physiology*
Reperfusion Injury / etiology
Reg. No./Substance:
0/Cell Adhesion Molecules

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Emerging paradigms of integrin ligand binding and activation.
Next Document:  Leukocyte migration in immune complex glomerulonephritis: role of adhesion receptors.