Document Detail

Leukocytes May Have 2 Opposing Effects in Intravenous rtPA Treatment for Ischemic Stroke.
MedLine Citation:
PMID:  22790658     Owner:  NLM     Status:  Publisher    
We hypothesized that leukocytes have 2 opposing effects on patients with ischemic stroke treated with recombinant tissue plasminogen activator (rtPA). Patients with ischemic stroke treated with rtPA were divided into 2 groups using the peripheral leukocyte count: high leukocyte group (HLG) and low leukocyte group (LLG) and were evaluated with the National Institutes of Health stroke scale (NIHSS) during the first 24 hours. We defined significant improvement (SI) as NIHSS improving by more than 50% from the baseline, and deterioration following improvement (DFI) as the achievement of SI within 24 hours but its subsequent loss at 24 hours. Fifty-three patients were enrolled, and the rate of SI within 24 hours was higher in HLG than in LLG (85.2% vs 42.3%, P = .0011). However, the rate of DFI was significantly higher in HLG than in LLG (29.6% vs 7.7%, P = .0413). We found that leukocytes might have not only deleterious but also beneficial effects in intravenous rtPA treatment.
Eiichi Nomura; Hiromitsu Naka; Shinichi Wakabayashi; Hiroshi Kajikawa; Masayasu Matsumoto
Related Documents :
11049098 - Sequential logistic models for 30 days mortality after cabg: pre-operative, intra-opera...
6233888 - Relative cost of coronary angioplasty and bypass surgery in a one-vessel disease model.
16388958 - Left ventricular reconstruction benefits patients with ischemic cardiomyopathy and non-...
18072418 - Acute renal failure post coronary artery bypass grafting at the university hospital of ...
16762008 - Endoscopic management of intrabiliary-ruptured hepatic hydatid cyst.
10735408 - Medium-term results after the modified cox/maze procedure combined with other cardiac s...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-11
Journal Detail:
Title:  Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis     Volume:  -     ISSN:  1938-2723     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9508125     Medline TA:  Clin Appl Thromb Hemost     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Analyzing the Effects of Platelet Gel on Knee Osteoarthritis in the Rat Model.
Next Document:  Association Between Neutrophil to Lymphocyte Ratio and Severity of Coronary Artery Disease.