| Leukocyte transepithelial migration in lung induced by DMSA functionalized magnetic nanoparticles. | |
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MedLine Citation:
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PMID: 20935452 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Magnetic nanoparticles surface-covered with meso-2,3-dimercaptosuccinic acid (MNPs-DMSA) constitute a promising approach for tissue- and cell-targeted delivery of therapeutic drugs in the lung. However, they can also induce a transient transendothelial migration of leukocytes in the organ as a side effect after endovenous administration of MNPs-DMSA. We demonstrated that monocytes/macrophages constitute the main subpopulation of leukocytes involved in this process. Our recent research found that MNPs-DMSA up-regulated the mRNA expression of E-, L- and P-selectin and macrophage-1 antigen, and increased concentration of tumor necrosis factor-α in lung, in a time dependent manner. The critical relevance of the β2 integrin-dependent pathway in leukocyte transmigration elicited by MNPs-DMSA was demonstrated by use of knockout mice. Our work characterizes mechanisms of the pro-inflammatory effects of MNPs-DMSA in the lung, and identifies β2 integrin-targeted interventions as promising strategies to reduce pulmonary side effects of MNPs-DMSA during biomedical applications. In addition, MNPs-DMSA could be used as modulators of lung immune response. |
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Authors:
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Ricardo Bentes Azevedo; Caroline Rodrigues Alves Valois; Sacha Braun Chaves; Jaqueline Rodrigues Silva; Monica Pereira Garcia |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-01-01 |
Journal Detail:
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Title: Cell adhesion & migration Volume: 5 ISSN: 1933-6926 ISO Abbreviation: Cell Adh Migr Publication Date: 2011 Jan-Feb |
Date Detail:
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Created Date: 2011-01-28 Completed Date: 2011-04-18 Revised Date: 2012-01-02 |
Medline Journal Info:
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Nlm Unique ID: 101469464 Medline TA: Cell Adh Migr Country: United States |
Other Details:
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Languages: eng Pagination: 29-33 Citation Subset: IM |
Affiliation:
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Department of Genetic and Morphology, Institute of Biology Science, University of Brasília, Brasília-DF, Brazil. razevedo@unb.br |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigens, CD18 / metabolism Leukocytes / drug effects*, metabolism Lung / drug effects* Macrophage-1 Antigen / drug effects, metabolism Macrophages / drug effects Magnetite Nanoparticles / administration & dosage* Mice P-Selectin / drug effects, metabolism Succimer / administration & dosage*, chemistry Transendothelial and Transepithelial Migration / drug effects* Tumor Necrosis Factor-alpha / drug effects, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD18; 0/Macrophage-1 Antigen; 0/Magnetite Nanoparticles; 0/P-Selectin; 0/Tumor Necrosis Factor-alpha; 304-55-2/Succimer |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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