Document Detail


Leukocyte trafficking and myocardial reperfusion injury in ICAM-1/P-selectin-knockout mice.
MedLine Citation:
PMID:  11123218     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
P-selectin and intercellular adhesion molecule-1 (ICAM-1) mediate early interaction and adhesion of neutrophils to coronary endothelial cells and myocytes after myocardial ischemia and reperfusion. In the present study, we examined the physiological consequences of genetic deletions of ICAM-1 and P-selectin in mice. In wild-type mice, after 1 h of ischemia followed by reperfusion, neutrophil influx into the area of ischemia was increased by 3 h with a peak at 24 h and a decline by 72 h. ICAM-1/P-selectin-deficient mice showed a significant reduction in neutrophils by immunohistochemistry or by myeloperoxidase activity at 24 h but no significant difference at 3 h. Infarct size (area of necrosis/area at risk) assessed 24 h after reperfusion was not different between wild-type and deficient mice after 30 min and 1 h of occlusion. Mice with a deficiency in both ICAM-1 and P-selectin have impaired neutrophil trafficking without a difference in infarct size due to myocardial ischemia-reperfusion.
Authors:
S A Briaud; Z M Ding; L H Michael; M L Entman; S Daniel; C M Ballantyne
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  280     ISSN:  0363-6135     ISO Abbreviation:  Am. J. Physiol. Heart Circ. Physiol.     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-02-02     Completed Date:  2001-02-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H60-7     Citation Subset:  IM    
Affiliation:
Section of Cardiovascular Sciences, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Immunohistochemistry
Intercellular Adhesion Molecule-1 / genetics,  physiology*
Leukocyte Count
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Myocardial Infarction / pathology
Myocardial Reperfusion Injury / pathology*
Myocardium / pathology
Neutrophil Infiltration*
P-Selectin / genetics,  physiology*
Peroxidase / metabolism
Grant Support
ID/Acronym/Agency:
HL-42550/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/P-Selectin; 126547-89-5/Intercellular Adhesion Molecule-1; EC 1.11.1.7/Peroxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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