Document Detail


Leukocyte-technetium-99m uptake in Crohn's disease: does it show subclinical disease?
MedLine Citation:
PMID:  20082484     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To evaluate inflammatory activity in patients with Crohn's disease (CD) using technetium-99m-hexamethylpropyleneamine oxime (99mTc-HMPAO) granulocyte scintigraphy.
METHODS: Twenty patients (7 male and 13 female) with CD and five healthy volunteers were selected for 99mTc-HMPAO granulocyte scintigraphy. The Crohn's Disease Activity Index (CDAI), blood tests and C-reactive protein (CRP) of each patient were performed 7 d before the scintigraphic images. The leukocytes were labeled according to the International Society of Radiolabeled Blood Elements (ISORBE) consensus protocol and the scintigraphic images, including single photon emission computed tomography, were obtained 30 min and 2 h after injection of the radiolabeled leukocytes.
RESULTS: The labeling yield of the leukocytes with the lipophilic complex 99mTc-HMPAO was 55.0% +/- 10%. Six of the 20 patients (30%) presented congruent results for the three parameters investigated (CDAI, Scintigraphic Index and CRP). On the other hand, 14 patients (70%) did not show congruent results. There was no significant correlation between the indices analyzed according to the Spearman test (P > 0.05, n = 20).
CONCLUSION: The results suggest that 99mTc-HMPAO-labeled leukocyte scintigraphy could be important for determining inflammatory activity in CD even in the absence of clinical symptoms.
Authors:
Luciene G Mota; Luiz G V Coelho; Carlos J R Simal; Maria L A Ferrari; Clodomiro Toledo; Josep Martin-Comin; Simone O F Diniz; Valbert N Cardoso
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  16     ISSN:  2219-2840     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-01-18     Completed Date:  2010-04-20     Revised Date:  2014-05-20    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  365-71     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
C-Reactive Protein / metabolism
Case-Control Studies
Crohn Disease / diagnosis,  metabolism*
Female
Humans
Inflammation / diagnosis,  metabolism
Leukocytes / metabolism*
Male
Middle Aged
Radionuclide Imaging
Radiopharmaceuticals / diagnostic use,  pharmacokinetics*
Sensitivity and Specificity
Severity of Illness Index*
Technetium Tc 99m Exametazime / diagnostic use,  pharmacokinetics*
Chemical
Reg. No./Substance:
0/Radiopharmaceuticals; 100504-35-6/Technetium Tc 99m Exametazime; 9007-41-4/C-Reactive Protein
Comments/Corrections

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