| Leukocyte removal therapy for ulcerative colitis does not affect postoperative complications. | |
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MedLine Citation:
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PMID: 17048048 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: We investigated the incidence of postoperative complications in patients treated with or without preoperative leukocyte removal therapy (LRT). METHODS: The case notes of 387 patients with ulcerative colitis (UC) who underwent surgical intervention were retrospectively reviewed. One hundred nine patients were treated with LRT within 8 weeks before surgery (LRT group), and 278 had not received LRT since at least 8 weeks before surgery (without LRT group). We reviewed the postoperative complications according to type of initial operation. RESULTS: Of the patients who underwent an ileal J-pouch anal anastomosis (IPAA) without an ileostomy, 3 (6.5%) in the LRT group developed pouch-related complications (PRC), while 11 (7.5%) in the without LRT group developed PRC. The overall postoperative complication rates were 28.3% in the LRT group and 21.8% in the without LRT group. For patients who underwent an IPAA with an ileostomy, the overall rates of postoperative complications were 39.1% in the LRT group and 31.8% in the without LRT group. Among those undergoing a total colectomy, 33.3% in the LRT group and 18.2% in the without LRT group had postoperative complications. No statistically significant differences were demonstrated between the two groups with respect to postoperative complications. CONCLUSIONS: Our results suggest that preoperative LRT does not influence the rate of postoperative complications in UC patients. |
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Authors:
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Hiroki Ikeuchi; Takehira Yamamura; Masato Kusunoki; Hiroki Nakano; Motoi Uchino; Mitsuhiro Nakamura; Masafumi Noda; Hidenori Yanagi; Takayuki Matsumoto |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of gastroenterology Volume: 41 ISSN: 0944-1174 ISO Abbreviation: J. Gastroenterol. Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-10-18 Completed Date: 2007-01-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9430794 Medline TA: J Gastroenterol Country: Japan |
Other Details:
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Languages: eng Pagination: 848-54 Citation Subset: IM |
Affiliation:
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Second Department of Surgery, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Colitis, Ulcerative / surgery* Colonic Pouches / adverse effects Female Follow-Up Studies Humans Incidence Leukocyte Reduction Procedures / methods* Male Middle Aged Postoperative Complications / epidemiology, prevention & control* Proctocolectomy, Restorative / adverse effects* Retrospective Studies Treatment Outcome |
| Comments/Corrections | |
Comment In:
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J Gastroenterol. 2006 Sep;41(9):923-4
[PMID:
17048060
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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