Document Detail

Leukocyte overshoot: a new sign of bioincompatibility in fast hemodialysis.
MedLine Citation:
PMID:  2252687     Owner:  NLM     Status:  MEDLINE    
A high blood flow of 400 ml/min induces leukocytosis after 2 hr of dialysis with leukocyte concentrations of 110-150% of predialysis values. The leukocytosis occurs with both low and high biocompatible membranes, such as Cuprophan, Hemophan, and Polyamide. Cuprophan induces the most profound leukopenia, and also induces the most pronounced leukocytosis. For treatments with a given membrane there was, however, no correlation between leukopenia and leukocytosis. Leukopenia was independent of blood flow, while leukocytosis was strongly influenced by this factor. These observations indicate that different factors cause leukopenia and leukocytosis. Although a larger area induced more leukopenia, the effect was small. Membrane area had no effect on leukocytosis. There were no acute clinical side effects during dialysis that could be related to the leukocyte overshoot. The cause and chronic clinical consequences of leukocyte overshoot are unknown.
P Kjellstrand; S H Jacobson; R Skröder; B Holmquist; U Boberg; L E Lins; P Okmark; C M Kjellstrand
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  ASAIO transactions / American Society for Artificial Internal Organs     Volume:  36     ISSN:  0889-7190     ISO Abbreviation:  ASAIO Trans     Publication Date:    1990 Jul-Sep
Date Detail:
Created Date:  1991-01-22     Completed Date:  1991-01-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8611947     Medline TA:  ASAIO Trans     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  M314-6     Citation Subset:  IM    
Gambro AB, Karolinska Hospital, University of Lund, Sweden.
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MeSH Terms
Aged, 80 and over
Blood Flow Velocity / physiology
Kidney Failure, Chronic / immunology*,  therapy
Kidney, Artificial*
Leukocyte Count*
Leukocytosis / immunology*
Leukopenia / immunology*
Membranes, Artificial*
Middle Aged
Reg. No./Substance:
0/Membranes, Artificial

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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