Document Detail


Leukocyte numbers correlate with plasma levels of granulocyte-macrophage colony-stimulating factor in sickle cell disease.
MedLine Citation:
PMID:  17205286     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Despite a clear role for leukocytes in modulating the pathophysiology of sickle cell disease (SCD), the mechanism by which leukocyte numbers are increased in this disorder remains unclear. Hypothesizing that the chronic inflammatory state, elicited by adhesive interactions involving various cell types, might underlie leukocytosis, we measured plasma levels of proinflammatory or myeloid cytokines that play a role in leukocytosis and examined their correlations with leukocyte numbers in patients with SCD. Our studies found that, although plasma levels of granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin 3, and macrophage colony-stimulating factor are elevated in steady-state patients with SCD, only plasma GM-CSF levels are positively correlated with the numbers of total leukocytes, neutrophils, monocytes, and eosinophils, regardless of whether they received hydroxyurea. GM-CSF levels were significantly decreased in patients on hydroxyurea therapy. These data suggest a role of GM-CSF in leukocytosis of SCD. In contrast, plasma levels of granulocyte colony-stimulating factor, a major cytokine that induces leukocytosis due to bacterial infection, were lower than those of control subjects. These results indicate that elevated GM-CSF levels may contribute, at least in part, to high leukocyte numbers in SCD. As plasma GM-CSF levels were decreased in patients on hydroxyurea therapy, hydroxyurea may decrease leukocyte numbers by reducing circulating GM-CSF levels.
Authors:
Nicola Conran; Sara T O Saad; Fernando F Costa; Tohru Ikuta
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2007-01-05
Journal Detail:
Title:  Annals of hematology     Volume:  86     ISSN:  1432-0584     ISO Abbreviation:  Ann. Hematol.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-02-26     Completed Date:  2007-12-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107334     Medline TA:  Ann Hematol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  255-61     Citation Subset:  IM    
Affiliation:
Hematology and Hemotherapy Center, University of Campinas, UNICAMP-SP, Campinas, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Anemia, Sickle Cell / blood*,  drug therapy
Case-Control Studies
Child
Eosinophils / cytology,  metabolism
Female
Granulocyte-Macrophage Colony-Stimulating Factor / blood*
Humans
Hydroxyurea / therapeutic use
Interleukin-3 / blood
Leukocyte Count
Leukocytosis / blood*
Lymphocytes / cytology,  metabolism
Macrophage Colony-Stimulating Factor / blood
Male
Monocytes / cytology,  metabolism
Neutrophils / cytology,  metabolism
Grant Support
ID/Acronym/Agency:
R01DK61806/DK/NIDDK NIH HHS; R01HL72345/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Interleukin-3; 127-07-1/Hydroxyurea; 81627-83-0/Macrophage Colony-Stimulating Factor; 83869-56-1/Granulocyte-Macrophage Colony-Stimulating Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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