Document Detail

Leukocyte migration is regulated by L-selectin endoproteolytic release.
MedLine Citation:
PMID:  14614858     Owner:  NLM     Status:  MEDLINE    
L-selectin mediates lymphocyte migration to peripheral lymph nodes and leukocyte rolling on vascular endothelium during inflammation. One unique feature that distinguishes L-selectin from other adhesion molecules is that it is rapidly cleaved from the cell surface after cellular activation. The biological significance of L-selectin endoproteolytic release was determined by generating gene-targeted mice expressing a modified receptor that was not cleaved from the cell surface. Blocking L-selectin cleavage on antigen-stimulated lymphocytes allowed their continued migration to peripheral lymph nodes and inhibited their short-term redirection to the spleen. Blocking homeostatic L-selectin cleavage also resulted in a constitutive 2-fold increase in overall L-selectin expression by leukocytes. As a result, neutrophils entered the inflamed peritoneum in greater numbers or for a longer duration. Thus, endoproteolytic cleavage regulates both homeostatic and activation-induced changes in cell surface L-selectin density, which directs the migration patterns of activated lymphocytes and neutrophils in vivo.
Guglielmo M Venturi; LiLi Tu; Takafumi Kadono; Adil I Khan; Yoko Fujimoto; Philip Oshel; Cheryl B Bock; Ann S Miller; Ralph M Albrecht; Paul Kubes; Douglas A Steeber; Thomas F Tedder
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Immunity     Volume:  19     ISSN:  1074-7613     ISO Abbreviation:  Immunity     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-11-17     Completed Date:  2003-12-18     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9432918     Medline TA:  Immunity     Country:  United States    
Other Details:
Languages:  eng     Pagination:  713-24     Citation Subset:  IM    
Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA.
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MeSH Terms
Cell Movement / physiology*
Endopeptidases / metabolism*
Gene Targeting
L-Selectin / blood,  genetics,  metabolism*
Leukocytes / metabolism*
Organ Specificity
Grant Support
Reg. No./Substance:
126880-86-2/L-Selectin; EC 3.4.-/Endopeptidases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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