Document Detail


Leukocyte migration inhibition studies and neutrophil cell function during aging in Nigerians.
MedLine Citation:
PMID:  8786667     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this study, in vitro cell-mediated immune response was analysed in 150 healthy Nigerians between 6 and 95 years old by the leukocyte migration inhibitory factor (L-MIF) test. Lymphocytes were activated with the mitogen concanavalin A and candida, measles virus and mycobacterial antigens. Nonspecific cellular immune capacity was studied by the Nitroblue tetrazolium (NBT) test. Numerical estimates of leukocytes and lymphocyte subpopulations were done. Mean L-MIF activity obtained with the four lymphocyte activators decreased with rising age indicating a progressive decline in cellular immune function with age. There was no significant age-related change in formazan positivity rate for both unstimulated and stimulated NBT tests. No age-related change in number was observed for any of the leucocyte and lymphocyte subpopulations. These results show that cell-mediaging response in Nigerians immunity declines, but phagocyte function is unchanged during aging. Lymphocyte depletion or numerical alteration in resting T cell subsets could not be demonstrated to be responsible for depressed cell-mediated immunity in aging Nigerians.
Authors:
G O Oyeyinka; L S Salimonu; O A Ladipo; A O Ashaye
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Mechanisms of ageing and development     Volume:  85     ISSN:  0047-6374     ISO Abbreviation:  Mech. Ageing Dev.     Publication Date:  1995 Nov 
Date Detail:
Created Date:  1996-09-20     Completed Date:  1996-09-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0347227     Medline TA:  Mech Ageing Dev     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  83-93     Citation Subset:  IM    
Affiliation:
Chemical Pathology and Immunology Department, University of Ilorin, Nigeria.
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Distribution
Aged
Aging / physiology*
Cell Migration Inhibition
Child
Humans
Leukocyte Migration-Inhibitory Factors / physiology*
Leukocytes / physiology*
Lymphocytes / physiology*
Middle Aged
Nigeria
Chemical
Reg. No./Substance:
0/Leukocyte Migration-Inhibitory Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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