| Leukocyte migration inhibition studies and neutrophil cell function during aging in Nigerians. | |
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MedLine Citation:
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PMID: 8786667 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this study, in vitro cell-mediated immune response was analysed in 150 healthy Nigerians between 6 and 95 years old by the leukocyte migration inhibitory factor (L-MIF) test. Lymphocytes were activated with the mitogen concanavalin A and candida, measles virus and mycobacterial antigens. Nonspecific cellular immune capacity was studied by the Nitroblue tetrazolium (NBT) test. Numerical estimates of leukocytes and lymphocyte subpopulations were done. Mean L-MIF activity obtained with the four lymphocyte activators decreased with rising age indicating a progressive decline in cellular immune function with age. There was no significant age-related change in formazan positivity rate for both unstimulated and stimulated NBT tests. No age-related change in number was observed for any of the leucocyte and lymphocyte subpopulations. These results show that cell-mediaging response in Nigerians immunity declines, but phagocyte function is unchanged during aging. Lymphocyte depletion or numerical alteration in resting T cell subsets could not be demonstrated to be responsible for depressed cell-mediated immunity in aging Nigerians. |
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Authors:
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G O Oyeyinka; L S Salimonu; O A Ladipo; A O Ashaye |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Mechanisms of ageing and development Volume: 85 ISSN: 0047-6374 ISO Abbreviation: Mech. Ageing Dev. Publication Date: 1995 Nov |
Date Detail:
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Created Date: 1996-09-20 Completed Date: 1996-09-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0347227 Medline TA: Mech Ageing Dev Country: IRELAND |
Other Details:
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Languages: eng Pagination: 83-93 Citation Subset: IM |
Affiliation:
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Chemical Pathology and Immunology Department, University of Ilorin, Nigeria. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Distribution Aged Aging / physiology* Cell Migration Inhibition Child Humans Leukocyte Migration-Inhibitory Factors / physiology* Leukocytes / physiology* Lymphocytes / physiology* Middle Aged Nigeria |
| Chemical | |
Reg. No./Substance:
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0/Leukocyte Migration-Inhibitory Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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