Document Detail


Leukocyte lipid bodies - Biogenesis and functions in inflammation.
MedLine Citation:
PMID:  19416659     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lipid body accumulation within leukocytes is a common feature in both clinical and experimental infectious, neoplasic and other inflammatory conditions. Here, we will review the contemporary evidence related to the biogenesis and structure of leukocyte lipid bodies (also known as lipid droplets) as inflammatory organelles. Studies of leukocyte lipid bodies are providing functional, ultrastructural and protein compositional evidences that lipid bodies are not solely storage depots of neutral lipid. Over the past years substantial progresses have been made to demonstrate that lipid body biogenesis is a highly regulated process, that culminate in the compartmentalization of a specific set of proteins and lipids, that place leukocyte lipid bodies as inducible cytoplasmic organelles with roles in cell signaling and activation, regulation of lipid metabolism, membrane trafficking and control of the synthesis and secretion of inflammatory mediators. Pertinent to the roles of lipid bodies in inflammation and cell signaling, enzymes involved in eicosanoid synthesis are localized at lipid bodies and lipid bodies are sites for eicosanoid generation. Collectively, lipid bodies in leukocytes are emerging as critical regulators of different inflammatory diseases, key markers of leukocyte activation and attractive targets for novel anti-inflammatory therapies.
Authors:
Patricia T Bozza; Kelly G Magalhães; Peter F Weller
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2009-01-21
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1791     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-08     Completed Date:  2009-09-10     Revised Date:  2013-06-24    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  540-51     Citation Subset:  IM    
Affiliation:
Laboratório de Imunofarmacologia, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Av. Brasil, 4365, Manguinhos, 21045-900, Rio de Janeiro, RJ, Brazil. pbozza@ioc.fiocruz.br
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Inflammatory Agents / pharmacology
Humans
Inflammation / immunology,  metabolism*,  prevention & control
Inflammation Mediators / metabolism
Leukocytes / drug effects,  immunology,  metabolism*
Lipid Metabolism* / drug effects
Organelles / drug effects,  immunology,  metabolism*
Protein Transport
Signal Transduction
Grant Support
ID/Acronym/Agency:
AI020241/AI/NIAID NIH HHS; AI022571/AI/NIAID NIH HHS; AI051645/AI/NIAID NIH HHS; R01 AI020241/AI/NIAID NIH HHS; R01 AI020241-24/AI/NIAID NIH HHS; R01 AI022571/AI/NIAID NIH HHS; R01 AI022571-21A2/AI/NIAID NIH HHS; R01 AI022571-23/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Inflammation Mediators
Comments/Corrections

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