Document Detail


Leukocyte and leukocyte subset counts reveal compensatory mechanisms in coronary heart disease.
MedLine Citation:
PMID:  23305798     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Leukocytes number in the circulation plays a central role in inflammatory diseases, such as coronary heart disease (CHD). Increased counts are correlated with the intensity of the peri-infarction inflammatory response and adverse outcomes. We investigated leukocyte and leukocyte subset counts in dyslipidaemia patients and their relationship with LDL oxidation. METHODS: Dyslipidaemia patients (207) were selected for blood counts and LDL-C testing. The level of HNP-1and myeloperoxidase in subsets of leukocytes and their relationship with LDL oxidation were compared between 24 CHD patients and 24 normal controls. RESULTS: In dyslipidaemia patients, total leukocyte and neutrophil counts increased with LDL-C (p=0.001). Monocyte counts showed the opposite trend (p=0.001). Although serum HNP-1 levels were not different between CHD patients and normal controls (p=0.558), neutrophil HNP-1 mRNA levels were 2.13-fold greater than those of normal controls. However, monocyte HNP-1 mRNA levels were lower (p=0.005). The distribution of myeloperoxidase in monocytes and neutrophils is different, myeloperoxidase locates mainly in the cytoplasm of monocytes, on the cell membrane of neutrophils. CONCLUSIONS: Leukocyte and leukocyte subset counts may correlate with LDL-C levels and LDL oxidation. The monocyte-neutrophil interaction reveals a potential compensatory mechanism associated with LDL oxidation in CHD that may be a prognostic factor of CHD.
Authors:
Jingwei Wang; Jian Song; Junzhu Wu; Chunyan He; Chengjie Xu; Yanhong Liu
Related Documents :
19784818 - Long-term prognostic value of coronary flow velocity reserve in patients with hypertrop...
18076548 - Sleeping hearts: the role of the heart in sleeping sickness (human african trypanosomia...
17957268 - The value of holter monitoring in the assessment of pediatric patients.
24412248 - Cerebrospinal fluid complement activation in patients with pneumococcal and meningococc...
7720438 - Safety of urgent restorative proctocolectomy with ileal pouch-anal anastomosis for fulm...
12130968 - Incidence, risk factors, and prognosis of a moderate increase in plasma creatinine earl...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-7
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  -     ISSN:  1873-3492     ISO Abbreviation:  Clin. Chim. Acta     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier B.V.
Affiliation:
Department of Biochemistry, School of Medicine, Wuhan University, Wuhan, 430071, P. R. China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Chemical Modulation of Crystalline State of Calcium Oxalate with Nickel Ions.
Next Document:  Detection of c.-32T>G (IVS1-13T>G) mutation of Pompe disease by real-time PCR in dried blood spots s...