Document Detail

Leukocyte and leukocyte subset counts reveal compensatory mechanisms in coronary heart disease.
MedLine Citation:
PMID:  23305798     Owner:  NLM     Status:  Publisher    
BACKGROUND: Leukocytes number in the circulation plays a central role in inflammatory diseases, such as coronary heart disease (CHD). Increased counts are correlated with the intensity of the peri-infarction inflammatory response and adverse outcomes. We investigated leukocyte and leukocyte subset counts in dyslipidaemia patients and their relationship with LDL oxidation. METHODS: Dyslipidaemia patients (207) were selected for blood counts and LDL-C testing. The level of HNP-1and myeloperoxidase in subsets of leukocytes and their relationship with LDL oxidation were compared between 24 CHD patients and 24 normal controls. RESULTS: In dyslipidaemia patients, total leukocyte and neutrophil counts increased with LDL-C (p=0.001). Monocyte counts showed the opposite trend (p=0.001). Although serum HNP-1 levels were not different between CHD patients and normal controls (p=0.558), neutrophil HNP-1 mRNA levels were 2.13-fold greater than those of normal controls. However, monocyte HNP-1 mRNA levels were lower (p=0.005). The distribution of myeloperoxidase in monocytes and neutrophils is different, myeloperoxidase locates mainly in the cytoplasm of monocytes, on the cell membrane of neutrophils. CONCLUSIONS: Leukocyte and leukocyte subset counts may correlate with LDL-C levels and LDL oxidation. The monocyte-neutrophil interaction reveals a potential compensatory mechanism associated with LDL oxidation in CHD that may be a prognostic factor of CHD.
Jingwei Wang; Jian Song; Junzhu Wu; Chunyan He; Chengjie Xu; Yanhong Liu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-7
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  -     ISSN:  1873-3492     ISO Abbreviation:  Clin. Chim. Acta     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier B.V.
Department of Biochemistry, School of Medicine, Wuhan University, Wuhan, 430071, P. R. China.
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