Document Detail

Leukocyte labile iron pool in patients with systolic heart failure.
MedLine Citation:
PMID:  22484774     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Data regarding sources of oxidative stress in the failing myocardium are sparse. Leukocytes actively participate in the oxidative damage observed in human heart failure (HF). The intracellular labile iron pool (LIP) represents a source of toxic reactive oxygen species.
METHODS: We studied patients with chronic systolic HF who had a left ventricular ejection fraction (LVEF) 45%. We examined the LIP status in different populations of leukocytes in HF patients and we investigated its association with clinical and laboratory parameters, including conventional inflammatory markers.
RESULTS: Sixty patients were finally included in the analysis (mean age: 67 ± 11 years, 54 men, 42 with ischemic cardiomyopathy). The multivariate logistic regression analysis showed that only LIP in granulocytes (OR: 0.73; 95% CI: 0.55-0.98; p=0.039) and right ventricular systolic pressure (RVSP) (OR: 0.95; 95% CI: 0.92-0.99; p=0.027) were independently associated with severe LV systolic dysfunction (LVEF30%). The correlation analysis revealed that LVEF was inversely associated with LIP in granulocytes (Spearman's rho: -0.39, p=0.002), LIP in monocytes (Spearman's rho: -0.35, p=0.007), and RVSP (Spearman's rho: -0.43, p=0.003). No significant correlation between LVEF and inflammatory indexes was noted.
CONCLUSIONS: LIP in granulocytes is independently associated with the severity of LV dysfunction in patients with systolic HF. Intracellular redox active iron may represent a source of leukocyte reactive oxygen species in this setting.
Panagiotis Korantzopoulos; Chara Vlachou; Anna Kotsia; Kallirroi Kalantzi; Alexandra Barbouti; Dimitrios Galaris; John A Goudevenos
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Hellenic journal of cardiology : HJC = Hellēnikē kardiologikē epitheōrēsē     Volume:  53     ISSN:  2241-5955     ISO Abbreviation:  Hellenic J Cardiol     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-04-09     Completed Date:  2012-08-14     Revised Date:  2013-08-07    
Medline Journal Info:
Nlm Unique ID:  101257381     Medline TA:  Hellenic J Cardiol     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  95-100     Citation Subset:  IM    
Department of Cardiology, University of Ioannina Medical School, Ioannina, Greece.
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MeSH Terms
Follow-Up Studies
Heart Failure, Systolic / metabolism*,  physiopathology
Iron / metabolism*
Leukocytes / metabolism*
Myocardium / metabolism*
Oxidative Stress
Reactive Oxygen Species / metabolism
Stroke Volume
Ventricular Function, Left / physiology*
Ventricular Pressure
Reg. No./Substance:
0/Reactive Oxygen Species; 7439-89-6/Iron

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