Document Detail

Leukocyte kinetics in the human lung: role of exercise and catecholamines.
MedLine Citation:
PMID:  6490458     Owner:  NLM     Status:  MEDLINE    
In six normal supine subjects epinephrine infusion produced a greater leukocytosis with smaller changes in heart rate and blood pressure than did norepinephrine or isoproterenol. Upright exercise in those subjects produced a greater leukocytosis than supine exercise at the same work load. To determine the lung's participation in these events, indium-labeled neutrophils (PMN) were given to four of the subjects. We found that 20-25% were retained in the first pass through the lung when compared with technetium-labeled erythrocytes. The number of labeled PMN in the lung gradually decreased and the number in the spleen and the liver increased. Exercise and catecholamine infusion caused an acceleration in the release of labeled cells from the lung, an increase in both labeled and unlabeled cells in the peripheral blood, and an increase in the number of labeled cells in the liver and spleen. This suggests that increased perfusion of low-flow areas in the lung may contribute to the increased leukocytosis seen in association with both exercise and catecholamine infusion.
A L Muir; M Cruz; B A Martin; H Thommasen; A Belzberg; J C Hogg
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of applied physiology: respiratory, environmental and exercise physiology     Volume:  57     ISSN:  0161-7567     ISO Abbreviation:  J Appl Physiol Respir Environ Exerc Physiol     Publication Date:  1984 Sep 
Date Detail:
Created Date:  1984-11-30     Completed Date:  1984-11-30     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  7801242     Medline TA:  J Appl Physiol Respir Environ Exerc Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  711-9     Citation Subset:  IM; S    
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MeSH Terms
Blood Pressure / drug effects
Catecholamines / pharmacology*
Cell Cycle
Epinephrine / pharmacology
Exercise Test
Heart Rate / drug effects
Indium / diagnostic use
Isoproterenol / pharmacology
Leukocytes / cytology*
Leukocytosis / etiology
Lung / cytology*
Norepinephrine / pharmacology
Physical Exertion*
Pulmonary Circulation
Radioisotopes / diagnostic use
Technetium / diagnostic use
Reg. No./Substance:
0/Catecholamines; 0/Radioisotopes; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 7440-26-8/Technetium; 7440-74-6/Indium; 7683-59-2/Isoproterenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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