| Leukocyte kinetics in the human lung: role of exercise and catecholamines. | |
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MedLine Citation:
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PMID: 6490458 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In six normal supine subjects epinephrine infusion produced a greater leukocytosis with smaller changes in heart rate and blood pressure than did norepinephrine or isoproterenol. Upright exercise in those subjects produced a greater leukocytosis than supine exercise at the same work load. To determine the lung's participation in these events, indium-labeled neutrophils (PMN) were given to four of the subjects. We found that 20-25% were retained in the first pass through the lung when compared with technetium-labeled erythrocytes. The number of labeled PMN in the lung gradually decreased and the number in the spleen and the liver increased. Exercise and catecholamine infusion caused an acceleration in the release of labeled cells from the lung, an increase in both labeled and unlabeled cells in the peripheral blood, and an increase in the number of labeled cells in the liver and spleen. This suggests that increased perfusion of low-flow areas in the lung may contribute to the increased leukocytosis seen in association with both exercise and catecholamine infusion. |
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Authors:
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A L Muir; M Cruz; B A Martin; H Thommasen; A Belzberg; J C Hogg |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of applied physiology: respiratory, environmental and exercise physiology Volume: 57 ISSN: 0161-7567 ISO Abbreviation: J Appl Physiol Publication Date: 1984 Sep |
Date Detail:
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Created Date: 1984-11-30 Completed Date: 1984-11-30 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7801242 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 711-9 Citation Subset: IM; S |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Pressure
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drug effects Catecholamines / pharmacology* Cell Cycle Epinephrine / pharmacology Erythrocytes Exercise Test Heart Rate / drug effects Humans Indium / diagnostic use Isoproterenol / pharmacology Leukocytes / cytology* Leukocytosis / etiology Lung / cytology* Male Norepinephrine / pharmacology Physical Exertion* Posture Pulmonary Circulation Radioisotopes / diagnostic use Technetium / diagnostic use |
| Chemical | |
Reg. No./Substance:
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0/Catecholamines; 0/Radioisotopes; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 7440-26-8/Technetium; 7440-74-6/Indium; 7683-59-2/Isoproterenol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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