Document Detail


Leukocyte glucose 6 phosphate dehydrogenase as prognostic indicator in ANLL and CML.
MedLine Citation:
PMID:  9315224     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Glucose 6 phosphate dehydrogenase (G6PD) was estimated in the leucocytes of 35 patients with acute non-lymphocytic leukemia (ANLL) and 10 patients with chronic myeloid leukemia (CML). G6PD levels were found to be significantly decreased in majority of the patients with ANLL while it was increased in all CML patients. Variation in G6PD was found to be dependent on the percentage of myelocytes inANLL. Cytogenetic analysis was also carried out in these patients. Correlation analysis of leucocyte G6PD activity and karyotype with prognostic assessment clearly indicated the association of (s) high percentage of chromosomal abnormalities especially translocations, (b) low survival and remission rates, with patients having decreased G6PD activity when compared to patients with normal activity in ANLL. The studies indicate that leucocyte G6PD may be useful as a diagnostic and prognostic tool.
Authors:
G S Devi; M H Prasad; P P Reddy; D N Rao
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Indian journal of experimental biology     Volume:  35     ISSN:  0019-5189     ISO Abbreviation:  Indian J. Exp. Biol.     Publication Date:  1997 Feb 
Date Detail:
Created Date:  1997-11-14     Completed Date:  1997-11-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0233411     Medline TA:  Indian J Exp Biol     Country:  INDIA    
Other Details:
Languages:  eng     Pagination:  155-8     Citation Subset:  IM    
Affiliation:
Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Begumpet, Hyderabad, India.
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MeSH Terms
Descriptor/Qualifier:
Chromosome Aberrations
Chromosome Disorders
Female
Glucosephosphate Dehydrogenase / blood*
Humans
Karyotyping
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / enzymology*,  genetics
Leukemia, Myeloid, Acute / enzymology*,  genetics
Leukocytes / enzymology*
Male
Prognosis
Tumor Markers, Biological
Chemical
Reg. No./Substance:
0/Tumor Markers, Biological; EC 1.1.1.49/Glucosephosphate Dehydrogenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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