Document Detail

Leukocyte function in healthy neonates following vaginal and cesarean section deliveries.
MedLine Citation:
PMID:  7097427     Owner:  NLM     Status:  MEDLINE    
Oxidative metabolic activities of polymorphonuclear leukocytes from cord blood of 15 full-term infants delivered by cesarean section without labor, five infants delivered by cesarean section with labor, and 15 infants delivered vaginally, as well as 35 healthy adult control subjects, were evaluated. The absolute polymorphonuclear leukocyte counts of cord blood from infants delivered vaginally and by cesarean section with labor were significantly higher when compared to cord blood APCs from infants delivered by cesarean section without labor and healthy adult control APCs. Zymosan-stimulated oxygen consumption, hexose monophosphate shunt activity, and quantitative nitroblue tetrazolium dye reduction were significantly lower in cord blood PMNLs from infants delivered vaginally and by cesarean section with labor than in cord blood PMNLs from infants delivered by cesarean section without labor or control PMNLs. Metabolic activity of PMNLs from healthy adults and infants born by cesarean section without labor did not differ significantly. This study indicates that the function of PMNLs isolated from cord blood varies with the method of delivery. These observations may explain previous discrepancies in the literature as well as the propensity of certain neonates to infection.
J P Frazier; T G Cleary; L K Pickering; S Kohl; P J Ross
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  101     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1982 Aug 
Date Detail:
Created Date:  1982-09-10     Completed Date:  1982-09-10     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  269-72     Citation Subset:  AIM; IM    
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MeSH Terms
Cesarean Section*
Delivery, Obstetric*
Fetal Blood / metabolism
Glucose / metabolism
Infant, Newborn*
Leukocyte Count
Neutrophils / metabolism*
Nitroblue Tetrazolium / metabolism
Oxygen Consumption
Grant Support
1-PO1-HD-13021/HD/NICHD NIH HHS; 5-507-RR05745/RR/NCRR NIH HHS
Reg. No./Substance:
298-83-9/Nitroblue Tetrazolium; 50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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