Document Detail

Leukocyte function in granuloma annulare.
MedLine Citation:
PMID:  475984     Owner:  NLM     Status:  MEDLINE    
Leukocytes from patients with granuloma annulare were studied in vitro in order to detect functional abnormalities. Random migration and chemotaxis of both polymorphonuclear leukocytes and monocytes were similar in patients and controls. Preincubation of normal cells with patients' plasma did not enhance or inhibit locomotion. Phagocytosis and oxidative burst as reflected by chemiluminescence were also normal. Peripheral blood lymphocytes incorporated uridine normally with and without stimulation by the non-specific mitogen phytohaemagglutinin. These studies suggest that peripheral blood leukocyte function in patients with granuloma annulare is normal, but do not exclude a functional abnormality in tissue.
K J Cherney; W E Lindroos; R W Goltz; M V Dahl
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The British journal of dermatology     Volume:  101     ISSN:  0007-0963     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  1979 Jul 
Date Detail:
Created Date:  1979-11-28     Completed Date:  1979-11-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  23-31     Citation Subset:  IM    
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MeSH Terms
Cell Movement
Chemotaxis, Leukocyte
Granuloma / physiopathology*
Leukocytes / physiology*
Luminescent Measurements
Lymphocyte Activation
Middle Aged
Monocytes / physiology
Neutrophils / physiology
Phytohemagglutinins / pharmacology
Skin Diseases / physiopathology*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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