| Leukocyte elastase inhibitor: a new regulator of PARP-1. | |
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MedLine Citation:
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PMID: 19723034 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Poly(ADP-ribose) polymerase-1 (PARP-1) uses NAD(+) as a substrate to form ADP-ribose. During apoptosis, caspases cleave PARP-1 to avoid excessive NAD consumption. Because PARP-1 is a key regulator of the activity of DNases involved in caspase-dependent apoptosis, its cleavage is required to promote DNA degradation. To explore the situation in caspase-independent cell death, we investigated the effect of PARP-1 on the acid endonuclease leukocyte elastase inhibitor (LEI)-derived DNase II (L-DNase II). We found for the first time an association between PARP-1 and LEI/L-DNase II. Unexpectedly, we observed that LEI influenced the automodification of PARP-1. |
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Authors:
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Chloé Leprêtre; Giuseppina Sidoli; A Ivana Scovassi; Alicia Torriglia |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Annals of the New York Academy of Sciences Volume: 1171 ISSN: 1749-6632 ISO Abbreviation: Ann. N. Y. Acad. Sci. Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-09-02 Completed Date: 2009-09-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7506858 Medline TA: Ann N Y Acad Sci Country: United States |
Other Details:
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Languages: eng Pagination: 25-31 Citation Subset: IM |
Affiliation:
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Université Pierre et Marie Curie-Paris 6, Paris, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Diphosphate Ribose
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metabolism* Animals Blotting, Western Cell Line Cell Nucleus / drug effects, metabolism Cytoplasm / drug effects, metabolism Electrophoresis, Polyacrylamide Gel Endodeoxyribonucleases / genetics, metabolism* Fluorescent Antibody Technique Hydrogen Peroxide / pharmacology Immunohistochemistry Leukocyte Elastase / metabolism NAD / metabolism Poly(ADP-ribose) Polymerases / metabolism* Recombinant Proteins / metabolism Swine |
| Chemical | |
Reg. No./Substance:
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0/Recombinant Proteins; 20762-30-5/Adenosine Diphosphate Ribose; 53-84-9/NAD; 7722-84-1/Hydrogen Peroxide; EC 2.4.2.30/Poly(ADP-ribose) Polymerases; EC 3.1.-/Endodeoxyribonucleases; EC 3.1.22.1/deoxyribonuclease II; EC 3.4.21.37/Leukocyte Elastase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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