| Leukocyte-derived growth factor links the PDGF and CXC chemokine families of peptides. | |
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MedLine Citation:
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PMID: 8836048 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Leukocytes produce many biological mediators that orchestrate the subsequent cellular events during wound healing. We have identified a novel cytokine, leukocyte-derived growth factor (LDGF), which is mitogenic for connective tissue cells. Sequence analysis of the LDGF peptide revealed that it is a precursor of other known peptides including platelet basic protein (PBP), connective tissue activating peptide III (CTAP-III), and neutrophil activating peptide 2 (NAP-2). None of these shorter peptides are active as mitogens for fibroblasts. LDGF appears to stimulate fibroblast growth by stimulation of tyrosine kinase activity of the PDGF receptors. One of the truncated products of LDGF, NAP-2, is a potent neutrophil chemoattractant. Peptides larger than NAP-2, such as PBP and CTAP-III, are not active as neutrophil chemoattractants. Collectively, these findings demonstrate that the LDGF peptide must remain intact in order to retain its fibroblast mitogenic activity. If the LDGF peptide is processed to release the carboxyl terminal half to generate NAP-2, a peptide with proinflammatory activity is generated. These results indicate that the multiple peptides produced from the LDGF-PBP gene posses divergent biological activities that could regulate different phases of the repair process. |
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Authors:
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N Iida; M Haisa; A Igarashi; D Pencev; G R Grotendorst |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: FASEB journal : official publication of the Federation of American Societies for Experimental Biology Volume: 10 ISSN: 0892-6638 ISO Abbreviation: FASEB J. Publication Date: 1996 Sep |
Date Detail:
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Created Date: 1996-11-14 Completed Date: 1996-11-14 Revised Date: 2012-02-15 |
Medline Journal Info:
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Nlm Unique ID: 8804484 Medline TA: FASEB J Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1336-45 Citation Subset: IM |
Affiliation:
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Department of Cell Biology and Anatomy, University of Miami School of Medicine, Florida 33101, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Chemokines / metabolism* Growth Substances* / genetics, isolation & purification, metabolism Humans Leukocytes / metabolism* Molecular Sequence Data Platelet-Derived Growth Factor / metabolism* Protein Precursors / genetics, isolation & purification, metabolism Recombinant Proteins / metabolism Sequence Alignment Sequence Analysis |
| Chemical | |
Reg. No./Substance:
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0/Chemokines; 0/Growth Substances; 0/Platelet-Derived Growth Factor; 0/Protein Precursors; 0/Recombinant Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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