| Leukocyte depleting filter attenuates myocardial injury during elective coronary artery bypass surgery. | |
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MedLine Citation:
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PMID: 16352489 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Ischemia-reperfusion injury secondary to leukocyte activation has been widely recognized as one of the most relevant mechanism leading to postoperative organ dysfunction occurring after a period of ischemia. The aim of the present study was to evaluate in a prospective, randomized study, the value of leukocyte depleting filter in patients undergoing elective coronary artery bypass surgery. METHODS: Twenty patients scheduled for elective on-pump coronary artery bypass surgery were randomized to undergo cardiopulmonary bypass either with a leukocyte depleting filter incorporated in the extracorporeal circulation arterial line or without a filter. RESULTS: The main finding of this study was the significantly lower postoperative concentrations of cardiac troponin I in the leukocyte filter group (Tests of between-subjects effects: p = 0.024). There were also slightly better cardiac indices in the leukocyte filter group. A larger amount of blood units was infused intra- and postoperatively in patients undergoing cardiopulmonary bypass with leukocyte filtration (median, 600 [IQR, 0-1200] vs. 0 [IQR, 0-600], p = 0.08). Two patients in the leukocyte filter group underwent reoperation for bleeding but none in the control group (p = 0.48). Intra-and postoperative platelet count was lower in the leukocyte filter group (Tests of between-subjects effects: p = 0.08). Despite a significant increased concentration of C-reactive protein on the first postoperative day in the control group (p = 0.029), repeated-measures analysis failed to show any significant increase during the study period (p = 0.33). CONCLUSIONS: The results of this study suggest a myocardial protective effect of leukocyte filter in the setting of elective coronary artery bypass surgery. |
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Authors:
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Juha Koskenkari; Jussi Rimpil?inen; Fausto Biancari; Helj?-Marja Surcel; P?ivi Kaukoranta; Kai Kiviluoma; Tero Ala-Kokko; Tatu Juvonen |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Scandinavian cardiovascular journal : SCJ Volume: 39 ISSN: 1401-7431 ISO Abbreviation: Scand. Cardiovasc. J. Publication Date: 2005 Dec |
Date Detail:
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Created Date: 2005-12-14 Completed Date: 2006-03-21 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9708377 Medline TA: Scand Cardiovasc J Country: England |
Other Details:
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Languages: eng Pagination: 358-68 Citation Subset: IM |
Affiliation:
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Division of Intensive Care, Department of Anesthesiology, Oulu University Hospital, Oulu, Finland. juha.koskenkari@fimnet.fi |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged C-Reactive Protein Cardiopulmonary Bypass / adverse effects, instrumentation, methods* Coronary Artery Bypass / adverse effects, methods* Female Hemodynamics Hemofiltration* Humans Leukocytes* Male Myocardial Reperfusion Injury / prevention & control* Myocardium / pathology* Prospective Studies Risk Factors Surgical Procedures, Elective |
| Chemical | |
Reg. No./Substance:
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9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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