Document Detail

Leukocyte counts in children with sickle cell disease. Comparative values in the steady state, vaso-occlusive crisis, and bacterial infection.
MedLine Citation:
PMID:  645659     Owner:  NLM     Status:  MEDLINE    
Total and differential WBC counts were measured in 88 children with sickle cell hemoglobinopathies during the steady state, vaso-occlusive crisis, and bacterial infection. Steady state leukocyte values were lower than anticipated on the basis of currently available information. Total and segmented leukocyte numbers were greatly increased during vaso-occlusive crisis and infection, but only with bacterial infection was there a consistent increase in bands or nonsegmented leukocytes (mean, 4,580/microliter). On the basis of these data we believe that total and differential leukocyte counts are of value for identifying those children with potentially serious bacterial infections.
G R Buchanan; B E Glader
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of diseases of children (1960)     Volume:  132     ISSN:  0002-922X     ISO Abbreviation:  Am. J. Dis. Child.     Publication Date:  1978 Apr 
Date Detail:
Created Date:  1978-06-12     Completed Date:  1978-06-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370471     Medline TA:  Am J Dis Child     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  396-8     Citation Subset:  AIM; IM    
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MeSH Terms
Anemia, Hemolytic, Congenital / blood
Anemia, Sickle Cell / blood*
Bacterial Infections / complications
Cell Count
Child, Preschool
Leukocytes / pathology*
Leukocytosis / complications
Sickle Cell Trait / blood*,  complications

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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