Document Detail


Leukocyte behavior in atherosclerosis, myocardial infarction, and heart failure.
MedLine Citation:
PMID:  23307733     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cardiovascular diseases claim more lives worldwide than any other. Etiologically, the dominant trajectory involves atherosclerosis, a chronic inflammatory process of lipid-rich lesion growth in the vascular wall that can cause life-threatening myocardial infarction (MI). Those who survive MI can develop congestive heart failure, a chronic condition of inadequate pump activity that is frequently fatal. Leukocytes (white blood cells) are important participants at the various stages of cardiovascular disease progression and complication. This Review will discuss leukocyte function in atherosclerosis, MI, and heart failure.
Authors:
Filip K Swirski; Matthias Nahrendorf
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  339     ISSN:  1095-9203     ISO Abbreviation:  Science     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-11     Completed Date:  2013-01-24     Revised Date:  2014-01-23    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  United States    
Other Details:
Languages:  eng     Pagination:  161-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adaptive Immunity
Animals
Atherosclerosis / complications,  immunology*,  physiopathology*
Disease Progression
Heart Failure / etiology,  immunology,  physiopathology*
Humans
Leukocytes / immunology,  physiology*
Macrophages / immunology,  physiology
Myocardial Infarction / etiology,  immunology,  physiopathology*
Grant Support
ID/Acronym/Agency:
R01 HL095612/HL/NHLBI NIH HHS; R01 HL095629/HL/NHLBI NIH HHS; R01 HL096576/HL/NHLBI NIH HHS; R01HL095612/HL/NHLBI NIH HHS; R01HL095629/HL/NHLBI NIH HHS; R01HL096576/HL/NHLBI NIH HHS
Comments/Corrections

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