| Leukocyte apoptosis and pro-/anti-apoptotic proteins following downhill running. | |
| | |
MedLine Citation:
|
PMID: 21424274 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
The purposes of this study were to determine the effect of eccentric exercise-induced muscle damage on the induction of apoptosis in peripheral blood leukocytes and to investigate if the elevation in apoptotic leukocytes was mediated by changes in the concentration of anti-/pro-apoptotic proteins in circulation. Twelve moderately trained subjects performed three 40 min treadmill runs at ~70% VO(2max): a level run (L) followed by two downhill runs (DH1 and DH2). Blood samples were taken at rest (PRE) and immediately (POST), 2, 24, and 48 h after each run. Data were analyzed using two-way repeated measures analysis of variance with post hoc Tukey tests. Creatine kinase (CK) activity was significantly elevated at 24 and 48 h following DH1 (P < 0.01). The proportion (%) of apoptotic leukocytes was significantly elevated at POST and 2 h following all three runs, and up to 48 h following DH1 (P < 0.01). Bax at 24-h post and Bax/Bcl-2 ratio at 24- (P < 0.01) and 48-h post (P < 0.05) following DH1 were greater than PRE (P < 0.05). An acute bout of moderate intensity downhill running altered CK activity, Bax concentration and the Bax/Bcl-2 ratio in circulating leukocytes resulting in a greater apoptotic response at 24- and 48-h post-exercise compared to level grade running or a second downhill run. Although the mechanism by which these proteins are altered by unaccustomed eccentric exercise is currently unknown, the differential response to DH1 versus L and DH2 indicates that it may be related to exercise-induced muscle damage. |
| | |
Authors:
|
Kyung-Shin Park; Darlene A Sedlock; James W Navalta; Man-Gyoon Lee; Seung-Hwan Kim |
Related Documents
:
|
628814 - Plasma citrate during submaximal and intermittent supramaximal exercise. 23190584 - Functional movement screen and aerobic fitness predict injuries in military training. 2843314 - Effects of opioid antagonism on the haemodynamic and hormonal responses to exercise. 21283744 - Regulation of pacing strategy during athletic competition. 10073794 - Comparison of perception of angina pectoris during exercise testing in african-american... 10466084 - Measurement of the respiratory burst and chemotaxis in polymorphonuclear leukocytes fro... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-3-19 |
Journal Detail:
|
Title: European journal of applied physiology Volume: - ISSN: 1439-6327 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-3-22 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100954790 Medline TA: Eur J Appl Physiol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Fitness and Sports Program, Texas A&M International University, 5201 University Blvd, Laredo, TX, 78041, USA , kpark@tamiu.edu. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Changes in Gay Men's Participation in Gay Community Life: Implications for HIV Surveillance and Rese...
Next Document: Child and Adolescent Emotion Regulation: The Role of Parental Emotion Regulation and Expression.