Document Detail

Leukocyte apoptosis and pro-/anti-apoptotic proteins following downhill running.
MedLine Citation:
PMID:  21424274     Owner:  NLM     Status:  Publisher    
The purposes of this study were to determine the effect of eccentric exercise-induced muscle damage on the induction of apoptosis in peripheral blood leukocytes and to investigate if the elevation in apoptotic leukocytes was mediated by changes in the concentration of anti-/pro-apoptotic proteins in circulation. Twelve moderately trained subjects performed three 40 min treadmill runs at ~70% VO(2max): a level run (L) followed by two downhill runs (DH1 and DH2). Blood samples were taken at rest (PRE) and immediately (POST), 2, 24, and 48 h after each run. Data were analyzed using two-way repeated measures analysis of variance with post hoc Tukey tests. Creatine kinase (CK) activity was significantly elevated at 24 and 48 h following DH1 (P < 0.01). The proportion (%) of apoptotic leukocytes was significantly elevated at POST and 2 h following all three runs, and up to 48 h following DH1 (P < 0.01). Bax at 24-h post and Bax/Bcl-2 ratio at 24- (P < 0.01) and 48-h post (P < 0.05) following DH1 were greater than PRE (P < 0.05). An acute bout of moderate intensity downhill running altered CK activity, Bax concentration and the Bax/Bcl-2 ratio in circulating leukocytes resulting in a greater apoptotic response at 24- and 48-h post-exercise compared to level grade running or a second downhill run. Although the mechanism by which these proteins are altered by unaccustomed eccentric exercise is currently unknown, the differential response to DH1 versus L and DH2 indicates that it may be related to exercise-induced muscle damage.
Kyung-Shin Park; Darlene A Sedlock; James W Navalta; Man-Gyoon Lee; Seung-Hwan Kim
Related Documents :
23145504 - Singing classes for chronic obstructive pulmonary disease: a randomized controlled trial.
23078424 - Punjabi sikh patients' perceived barriers to engaging in physical exercise following my...
24198564 - A comparison of cytokine responses during prolonged cycling in normal and hot environme...
25142094 - Ramping up the signal: promoting endurance training adaptation in skeletal muscle by nu...
16004904 - Relationship between echocardiographic and aerobic capacity parameters in distance runn...
21514694 - Measuring the impact of exercise on cognitive aging: methodological issues.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-19
Journal Detail:
Title:  European journal of applied physiology     Volume:  -     ISSN:  1439-6327     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100954790     Medline TA:  Eur J Appl Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Fitness and Sports Program, Texas A&M International University, 5201 University Blvd, Laredo, TX, 78041, USA ,
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Changes in Gay Men's Participation in Gay Community Life: Implications for HIV Surveillance and Rese...
Next Document:  Child and Adolescent Emotion Regulation: The Role of Parental Emotion Regulation and Expression.