Document Detail

Leukocyte Telomere Length in Hiv-Infected Pregnant Women Treated withAntiretroviral Drugs During Pregnancy and Their Uninfected Infants.
MedLine Citation:
PMID:  22580562     Owner:  NLM     Status:  Publisher    
OBJECTIVES:: HIV disease can lead to accelerated telomere attrition while certain drugs used as part of antiretroviral therapy (ART) can inhibit telomerase reverse transcriptase activity. This could in turn lead to shorter telomeres. We hypothesized that HIV and ART exposure would be associated with shorter leukocyte telomere length (TL) in exposed mother/infant pairs compared to controls. METHODS:: In these retrospective and prospective observational cohort studies, TL was evaluated in peripheral blood leukocytes obtained from HIV-infected pregnant women treated with ART and their uninfected infants, and compared with HIV untreated (retrospective cohort) or HIV- mothers and their infants (prospective cohort). RESULTS:: In HIV-infected ART-exposed mothers, leukocyte TL was not significantly shorter than in HIV untreated mothers or HIV controls, nor was their infants' TL significantly different. Cord blood of ART-exposed infants exhibited TL shorter than that from infants born to HIV mothers. Placenta also showed evidence of shorter TL after adjustment for relevant covariates. Factors associated with shorter maternal and infant TL included smoking and use of drugs of addiction in pregnancy. CONCLUSIONS:: These results suggest that maternal HIV infection or exposure to ART has minimal effect on infant leukocyte TL, a reassuring finding. In contrast, tissues that express higher telomerase activity such as umbilical cord blood and placenta appear comparatively more affected by ART. Smoking and use of drugs of addiction have a negative impact on maternal and infant leukocyte TL, possibly through oxidative telomere damage.
Imam Tuhina; Jitratkosol Marissa H J; Soudeyns Hugo; Sattha Beheroze; Gadawski Izabelle; Maan Evelyn; Forbes John C; Alimenti Ariane; Lapointe Normand; Lamarre Valerie; Money Deborah M; Côté Hélène C F;
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-10
Journal Detail:
Title:  Journal of acquired immune deficiency syndromes (1999)     Volume:  -     ISSN:  1944-7884     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100892005     Medline TA:  J Acquir Immune Defic Syndr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1Department of Pathology & Laboratory Medicine, University of British Columbia, Vancouver, Canada 2Hôpital Ste-Justine, Montreal, Canada 3Children's and Women's Health Centres of BC, Vancouver, Canada 4Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, Canada 5Women's Health Research Institute, Vancouver, Canada 6Centre for Blood Research, Vancouver, Canada.
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