Document Detail

Leukoaraiosis is associated with functional impairment in older patients with Alzheimer's disease but not vascular dementia.
MedLine Citation:
PMID:  16453055     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Leukoaraiosis (LA) is a common finding in older persons, and might be associated with reduced cognitive performance, gait abnormalities, and functional impairment. Although LA is more frequent in persons affected by dementia, scant data are available about its clinical consequences in this group of patients. OBJECTIVE: To study the association between presence of LA and functional performance in basic activities of daily living in a sample of older persons affected by dementia. DESIGN: We conducted a cross-sectional study on 214 patients; 77 affected by late onset Alzheimer's disease (LOAD), and 137 by vascular dementia (VD). Functional status was assessed using Barthel Index (BI). LA was assessed using computed tomography. RESULTS: In LOAD patients, LA (OR: 7.87; 1.26-48.94), and MMSE score (OR: 0.83; 0.71-0.98) were associated with the risk of severe disability, independent of age, gender, diabetes, hypertension, coronary heart disease, left ventricular hypertrophy, atrial fibrillation, and brain atrophy. In VD patients, MMSE score (OR: 0.77; 0.64-0.93), and CHD (OR: 7.41; 1.09-50.21), but not LA (OR: 2.07; 0.45-9.45) were associated with a severe functional impairment after multivariate adjustment. CONCLUSIONS: Our study suggests that LA might be associated with a worse functional status in basic activities of daily living in patients affected by LOAD but not VD. LA might act synergistically with cognitive and behavioural disturbances to the onset and progression of disability of these patients.
A Ble; M Ranzini; A Zurlo; L Menozzi; A R Atti; M R Munari; S Volpato; G Scaramelli; R Fellin; G Zuliani
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The journal of nutrition, health & aging     Volume:  10     ISSN:  1279-7707     ISO Abbreviation:  J Nutr Health Aging     Publication Date:    2006 Jan-Feb
Date Detail:
Created Date:  2006-02-02     Completed Date:  2006-04-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100893366     Medline TA:  J Nutr Health Aging     Country:  France    
Other Details:
Languages:  eng     Pagination:  31-5     Citation Subset:  IM    
Department of Clinical and Experimental Medicine, Section of Internal Medicine, Gerontology and Geriatrics; University of Ferrara, Via Savonarola no. 9, 44100 Ferrara, ITALY.
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MeSH Terms
Activities of Daily Living
Aged, 80 and over
Alzheimer Disease / pathology*
Analysis of Variance
Brain / radiography
Cross-Sectional Studies
Dementia, Vascular / pathology*
Leukoaraiosis / complications*,  pathology*,  physiopathology
Logistic Models
Severity of Illness Index
Tomography, X-Ray Computed

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