| Leukoaraiosis is associated with arterial wall thickness: A quantitative analysis. | |
| | |
MedLine Citation:
|
PMID: 22017293 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Leukoaraiosis refers to an age-related, abnormal appearance of the brain white matter on neuroimaging. The association between leukoaraiosis and cerebrovascular disease suggests that ischemia may be an important contributing factor; however, the pathogenesis of the condition remains controversial. We hypothesized that physical abnormalities of blood vessels might be culpable and compared the external and internal measurements of blood vessel walls between brains that demonstrated leukoaraiosis on imaging and normal control brains. Fourteen brains of individuals who had been diagnosed as having severe leukoaraiosis and five non-leukoaraiosis control brains were studied. Arterial cross-sections were evaluated by length measurements with an image analysis device. Arterial wall thickness and the ratio of the outer and inner diameters of the vessel were measured. We measured a total of 108 vessels in the leukoaraiosis group and 95 vessels in the control group. The vessel walls of the leukoaraiosis patients were an average of 5.5 µm thicker than the walls of control vessels of the same inside diameter (P = 0.0000, 95% CI 3.01-8.08) and an average of 2.3 µm thicker than walls of control vessels of the same outside diameter (P = 0.016, 95% CI 0.48-4.17). Our data provide evidence that leukoaraiosis is associated with vessel wall thickening in an additive fashion and indicate that structural vascular abnormalities are associated with leukoaraiosis. |
| | |
Authors:
|
Eitan Auriel; Laszlo Csiba; Ervin Berenyi; Ildiko Varkonyi; Gabor Mehes; Laszlo Kardos; Arnon Karni; Natan M Bornstein |
Related Documents
:
|
8958533 - Choroidal detachment associated with direct spontaneous carotid-cavernous sinus fistula. 9537663 - Sagittal sinus thrombosis following minor head injury treated with continuous urokinase... 11259813 - A method for investigating the mechanical properties of intracoronary stents using fini... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-10-24 |
Journal Detail:
|
Title: Neuropathology : official journal of the Japanese Society of Neuropathology Volume: - ISSN: 1440-1789 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
|
Created Date: 2011-10-24 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9606526 Medline TA: Neuropathology Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© 2011 Japanese Society of Neuropathology. |
Affiliation:
|
Stroke Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel Debrecen University, Medical and Health Science Center Debrecen Infection Control Unit, Kenezy Hospital Debrecen, Debrecen, Hungary. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Renal histological lesions and outcome in liver transplant recipients.
Next Document: Delays in psychiatric drug development in Japan.