| Leukoaraiosis and collaterals in acute ischemic stroke. | |
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MedLine Citation:
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PMID: 20977524 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: We examined the correlation of angiographic collaterals in acute stroke with the presence, extent, and distribution of white matter changes, so-called Leukoaraiosis, in an effort to determine if Leukoaraiosis indicates chronic cerebral hypoperfusion and/or is associated with the development of cerebral collateral circulation. METHODS: Consecutive acute strokes due to large-vessel occlusion on angiography had preprocedure CT or MRI white matter changes graded utilizing the Fazekas scale incorporating deep and periventricular components. Angiographic collaterals evaluated with a 5-point scale were correlated with leukoaraiosis. RESULTS: Collaterals were evaluated in 102 cases (51 men, 51 women; mean age 66 (SD 18) years with acute occlusions of the proximal middle cerebral artery (MCA) (47%), distal internal carotid artery (ICA) (28%), distal MCA (9%), basilar (7%), proximal ICA (7%), vertebral (1%), posterior cerebral artery (PCA) (1%), and common carotid artery (CCA) (1%). Collateral grade was well distributed across the scale. Periventricular and deep white matter changes were evident in 34% and 51% of cases, respectively. Collateral grade exhibited no relationship with either the presence or extent of periventricular disease (P= .772, r= .029) or deep white matter changes (P= .559, r=-.059). CONCLUSIONS: Leukoaraisosis exhibits no overt relationship with the extent of collaterals measured at angiography in acute ischemic stroke. Chronic small-vessel disease may be a distinct pathophysiologic entity unrelated to arteriogenesis and compensatory aspects of collateral flow. |
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Authors:
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Nerses Sanossian; Bruce Ovbiagele; Jeffrey L Saver; Jeffry R Alger; Sidney Starkman; Doojin Kim; Arbi G Ohanian; Brian H Buck; Latisha K Ali; Gary R Duckwiler; Reza Jahan; Fernando Viñuela; David S Liebeskind |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-10-26 |
Journal Detail:
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Title: Journal of neuroimaging : official journal of the American Society of Neuroimaging Volume: 21 ISSN: 1552-6569 ISO Abbreviation: J Neuroimaging Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-06-28 Completed Date: 2011-10-28 Revised Date: 2012-09-19 |
Medline Journal Info:
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Nlm Unique ID: 9102705 Medline TA: J Neuroimaging Country: United States |
Other Details:
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Languages: eng Pagination: 232-5 Citation Subset: IM |
Copyright Information:
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© 2010 by the American Society of Neuroimaging. |
Affiliation:
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Department of Neurology, University of Southern California, CA, USA. sanossia@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Brain / blood supply, pathology, radiography* Brain Ischemia / pathology, radiography* Cerebral Angiography Cerebrovascular Circulation Collateral Circulation* Female Humans Leukoaraiosis / pathology, radiography* Male Middle Aged Retrospective Studies Stroke / pathology, radiography* |
| Grant Support | |
ID/Acronym/Agency:
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K23 NS054084-01A1/NS/NINDS NIH HHS; K23NS054084/NS/NINDS NIH HHS |
| Comments/Corrections | |
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