Document Detail

Leukemic phase of B-cell lymphomas mimicking chronic lymphocytic leukemia and variants at presentation.
MedLine Citation:
PMID:  12429788     Owner:  NLM     Status:  MEDLINE    
Six cases of non-Hodgkin B-cell lymphoma that mimicked either chronic lymphocytic leukemia (CLL) or a CLL variant at presentation are reported. The patients ranged from 54 to 89 years and included three females and three males. All six patients had prominent peripheral blood lymphocytosis at presentation; the initial morphologic impression was CLL in three cases, CLL/prolymphocytic leukemia (PLL) in two cases, and PLL in one. Five patients had bone marrow biopsies; each showed a lymphoid infiltrate in a focally random, interstitial, and/or diffuse pattern. Flow cytometric immunophenotyping showed CD20-positive B cells with surface immunoglobulin (Ig) light chain restriction in all six patients. The five cases resembling CLL or CLL/PLL had at least a subset of CD5-positive B cells, whereas CD5 was absent in the one case that resembled PLL. CD23 was positive in three of the four cases studied that resembled CLL or CLL/PLL; CD79b was positive in three, FMC7 was positive in two, and surface Ig and CD20 were brightly positive in three. A t(11;14) (q13;q32) was found in four cases that resembled CLL or CLL/PLL; they were subsequently diagnosed as mantle cell lymphoma. The remaining two cases mimicking CLL or PLL were diagnosed as lymphomas of follicle center origin with leukemic phase based on the presence of t(14;18) (q32;q21). Thus although the morphology of these six cases resembled CLL or variants, and immunophenotyping by flow cytometry showed overlapping features, genetic studies enabled distinction of these leukemic non-Hodgkin lymphoma from chronic lymphocytic leukemia or variants.
Beverly P Nelson; Daina Variakojis; LoAnn C Peterson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc     Volume:  15     ISSN:  0893-3952     ISO Abbreviation:  Mod. Pathol.     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-11-13     Completed Date:  2003-04-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8806605     Medline TA:  Mod Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1111-20     Citation Subset:  IM    
Section of Hematopathology, Northwestern University Medical School, Chicago, Illinois 60611, USA.
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MeSH Terms
Aged, 80 and over
Chromosomes, Human, Pair 11 / genetics
Chromosomes, Human, Pair 14 / genetics
Chromosomes, Human, Pair 18 / genetics
Cyclin D1 / analysis
Diagnosis, Differential
Flow Cytometry
In Situ Hybridization, Fluorescence
Leukemia, Lymphocytic, Chronic, B-Cell / genetics,  immunology,  pathology*
Lymphoma, B-Cell / genetics,  immunology,  pathology*
Middle Aged
Translocation, Genetic
Reg. No./Substance:
136601-57-5/Cyclin D1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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