Document Detail

Leukemic differentiation of a mediastinal germ cell tumor.
MedLine Citation:
PMID:  2562115     Owner:  NLM     Status:  MEDLINE    
The biological basis for acute leukemia associated with mediastinal germ cell tumors has remained unexplained due to lack of critical data that would illuminate the genetic relationship between the two tumors in a given patient. Here we present results of serial cytogenetic investigations on the pretreatment and posttreatment mediastinal yolk sac tumor and immature teratoma biopsies and two separate leukemic bone marrow aspirates from a patient who developed acute nonlymphocytic leukemia 11 months after the initial diagnosis of the germ cell tumor. Presence of an i(12p) in all tumor clones and trisomy 21 in one clone in the posttreatment mediastinal tumor and all leukemic clones establishes the common origin of all tumor clones and shows that in this case the leukemia was derived from the malignant germ cell clone.
R S Chaganti; M Ladanyi; F Samaniego; K Offit; V E Reuter; S C Jhanwar; G J Bosl
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Genes, chromosomes & cancer     Volume:  1     ISSN:  1045-2257     ISO Abbreviation:  Genes Chromosomes Cancer     Publication Date:  1989 Sep 
Date Detail:
Created Date:  1991-03-13     Completed Date:  1991-03-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9007329     Medline TA:  Genes Chromosomes Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  83-7     Citation Subset:  IM    
Laboratory of Cancer Genetics and Cytogenetics, Sloan-Kettering Institute, New York, New York.
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MeSH Terms
Bone Marrow / pathology
Cell Differentiation / genetics
Leukemia, Myeloid, Acute / genetics*,  pathology
Mediastinal Neoplasms / genetics*,  pathology
Mesonephroma / genetics,  pathology
Neoplasms, Germ Cell and Embryonal / genetics*,  pathology
Neoplasms, Multiple Primary / genetics*,  pathology
Teratoma / genetics,  pathology
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