Document Detail


Leukemia presenting as solid tumors: report of four pediatric cases and review of the literature.
MedLine Citation:
PMID:  18179285     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Leukemias are neoplasms that arise from the hematopoetic cells of bone marrow and usually spread first to peripheral blood. Involvement of extramedullary tissue during the course of a leukemia is common and usually does not represent a major diagnostic challenge when the history is available and specimen triage is optimal. In the context of a myeloid origin, extramedullary leukemias are referred to as granulocytic sarcomas, extramedullary myeloid tumors, extramedullary leukemias, or myeloid sarcomas. In the lymphoid category, leukemia involvement of tissue is conventionally distinguished from lymphoma by establishing the presence of 20% or more blasts in the bone marrow. A leukemia with an initial presentation outside the bone marrow mimicking a solid tumor is a rare but well-documented clinical encounter. Diagnostic difficulties may arise, especially when a specimen is not triaged properly due to the clinical presumption of a nonhematopoietic tumor. Systematic handling and proper triaging of biopsies are the keys to reducing diagnostic error and facilitating a timely diagnosis in this category. We report 4 case examples in the pediatric population, presenting in different anatomic sites. The value of fresh specimens and performing touch imprints is discussed and emphasized.
Authors:
Latha Urs; Lisa Stevens; Samir B Kahwash
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Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2008-01-07
Journal Detail:
Title:  Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society     Volume:  11     ISSN:  1093-5266     ISO Abbreviation:  Pediatr. Dev. Pathol.     Publication Date:    2008 Sep-Oct
Date Detail:
Created Date:  2008-11-13     Completed Date:  2009-01-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9809673     Medline TA:  Pediatr Dev Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  370-6     Citation Subset:  IM    
Affiliation:
Department of Laboratory Medicine, Nationwide Children's Hospital, OH 43205, USA.
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MeSH Terms
Descriptor/Qualifier:
Child
Child, Preschool
Fatal Outcome
Female
Follow-Up Studies
Humans
Immunophenotyping
Infant
Leukemia, Myeloid, Acute / drug therapy,  pathology*
Leukemia, Myelomonocytic, Juvenile / pathology*
Male
Neoplasms / drug therapy,  pathology*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology*
Pregnancy
Pregnancy Trimester, First
Time Factors
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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