Document Detail

Leukemia in radiation-treated patients: cytogenetic studies in eight cases.
MedLine Citation:
PMID:  282809     Owner:  NLM     Status:  MEDLINE    
Abnormal chromosomes have been found in various clinical settings and in cancer patients. Eight patients developed leukemia several years after the diagnosis and treatment of a primary malignant disease. All the patients were being treated with irradiation, and five of them also received chemotherapy, notably, alkylating agents. The type of leukemias and the interval between irradiation and leukemia parallel very well with those reported from the atomic bomb casualties. Chromosomal abnormalities were seen in all the patients. These abnormalities have been reported in irradiated normal persons without developed leukemias. These findings suggest that the development of clinical cancer or leukemia may depend, not only on the presence of abnormal cells, but also on other factors. Perhaps the environment that allowed the original cancer to develop in our patients is capable of allowing the radiation-induced abnormal cells to be expressed as clinical leukemia.
K O Goh; A Bauman; R Bakemeier; H Lee; J E Woll
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The American journal of the medical sciences     Volume:  276     ISSN:  0002-9629     ISO Abbreviation:  Am. J. Med. Sci.     Publication Date:    1978 Sep-Oct
Date Detail:
Created Date:  1979-03-28     Completed Date:  1979-03-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370506     Medline TA:  Am J Med Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  189-95     Citation Subset:  AIM; IM    
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MeSH Terms
Acute Disease
Child, Preschool
Chromosome Aberrations*
Chronic Disease
Leukemia, Lymphoid / etiology
Leukemia, Myeloid / etiology
Leukemia, Myeloid, Acute / etiology
Leukemia, Radiation-Induced / genetics*
Middle Aged
Neoplasms / radiotherapy*
Radiotherapy / adverse effects*
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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