Document Detail

Leukemia cutis in congenital leukemia. Analysis and review of the world literature with report of an additional case.
MedLine Citation:
PMID:  8215495     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Congenital leukemia cutis is rarely reported in the dermatology literature despite various authors citing 50% of infants with congenital leukemia have skin involvement. These seemingly disparate facts prompted a review of the world literature that was performed by searching the MEDLINE database from 1966 up to and through December 1992, reviewing Index Medicus for the years prior to computerized MEDLINE search, and reviewing appropriate case report references. OBSERVATIONS: A 2-month premature male infant was born with 182 x 10(9)/L circulating monoblasts, prominent hepatosplenomegaly, and multiple firm blue and red cutaneous nodules. CONCLUSION: Approximately 175 cases of congenital leukemia have been reported with at least 41 and possibly 56 cases identified with leukemia cutis. Specific cutaneous leukemic infiltrates occur in 25% to 30% of infants with congenital leukemia and usually appear as firm blue, red, or purple nodules in a generalized distribution. In contrast to the 50% incidence of gingival and oral infiltrates reported in adult monocytic leukemia, only 1% of congenital leukemia patients have oral involvement. Congenital leukemia cutis may precede other manifestations of leukemia by as much as 4 months. Whereas leukemia cutis is associated with a poor prognosis in adult leukemics, the natural history of congenital leukemia is not altered by leukemia cutis.
K S Resnik; B B Brod
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Archives of dermatology     Volume:  129     ISSN:  0003-987X     ISO Abbreviation:  Arch Dermatol     Publication Date:  1993 Oct 
Date Detail:
Created Date:  1993-11-02     Completed Date:  1993-11-02     Revised Date:  2008-03-17    
Medline Journal Info:
Nlm Unique ID:  0372433     Medline TA:  Arch Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1301-6     Citation Subset:  AIM; IM    
Division of Dermatology, Hahnemann University Hospital, Philadelphia, Pa.
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MeSH Terms
Infant, Newborn
Infant, Premature
Leukemia / congenital*,  diagnosis,  pathology
Leukemic Infiltration*
Skin / pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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