Document Detail

Leukapheresis in the treatment of cutaneous T-cell lymphomas.
MedLine Citation:
PMID:  3488757     Owner:  NLM     Status:  MEDLINE    
In six patients with cutaneous T-cell lymphomas (CTCL), the effect of leukapheresis (LPH) on the disease and on various immunological and haematological parameters was investigated. Enriched mononuclear cells were removed by continuous centrifugation leukapheresis from the peripheral blood of the patients. A profound and longlasting effect was seen in one patient with the Sézary variant; a moderate response was seen in two other Sézary patients. No benefit was observed in two patients with more aggressive leukaemic disease, and one patient with plaque stage MF responded on two occasions. No limiting side effects were recognized and no consistent changes of immunological or haematological parameters were observed after LPH.
S V Belter; J Knop; K Brüske; C Sorg
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of dermatology     Volume:  115     ISSN:  0007-0963     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  1986 Aug 
Date Detail:
Created Date:  1986-10-06     Completed Date:  1986-10-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  159-66     Citation Subset:  IM    
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MeSH Terms
Immunoglobulins / biosynthesis
Lymphocyte Activation
Lymphoma / immunology,  therapy*
Middle Aged
Skin Neoplasms / immunology,  therapy*
Reg. No./Substance:

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